Mounjaro Side Effects: Realistic Week-by-Week Timeline, Tirzepatide-Specific Differences, and When to Stop (June 2026)

Nausea hits 18-22% of Mounjaro patients in SURPASS trials. Constipation hits 17%, diarrhea 17%, vomiting 8-13%. The tirzepatide-specific pattern: more constipation than semaglutide (GIP receptor's effect on gut motility), more weight loss, and the GI tolerability profile peaks slightly later in titration. Most side effects resolve in 4-6 weeks; constipation can persist for months. Here's the realistic week-by-week timeline, what to actually do, the 5 red flags that mean stop, and the cheaper paths if Mounjaro's $1,069/month cash price is what would push you to quit before the side effects settle.