ShedRx vs Trimi: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of ShedRx and Trimi to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend ShedRx
Between these two providers, ShedRx is our pick for most users. It offers a higher overall rating (8.8 vs 8.3), availability in all 50 states, both brand-name and compounded medication options. That said, Trimi may be the better fit if you are looking for cash-pay users who want the cheapest tirzepatide from a us-licensed program.
ShedRx scores 8.8/10 in our independent evaluation at $199/month, while Trimi scores 8.3/10 at $99/month. Both programs include a licensed physician consultation and ship medication directly to your door. ShedRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | ShedRx | Trimi |
|---|---|---|
| Monthly Price | $199 | $99 |
| Rating | 8.8 / 10 | 8.3 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 47 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, health coaching, supplement guidance | US-licensed clinicians, telehealth consults, dose adjustments |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
ShedRx: Detailed Look
ShedRx
150K+ members with 5 medication forms — injections, oral drops, lozenges, tablets, and pills
Pros
- Most delivery forms of any provider: injections, oral drops, lozenges, tablets, and pills
- 10% weight loss guarantee within 9 months or full refund
- Both compounded and brand-name options (Wegovy, Zepbound)
- 150,000+ members, health coaching and supplements included
Cons
- Price increases at higher doses (up to $299/mo)
- Mixed customer service reviews — communication speed can lag
Users who want multiple medication delivery forms and a money-back weight loss guarantee
Trimi: Detailed Look
Trimi
Compounded GLP-1 from $99 with US-licensed clinicians
Pros
- Tirzepatide at $125/month — lowest tirzepatide price among verified programs
- Semaglutide at $99/month matches the market floor
- US-licensed clinicians with dose-adjustment support
- Free shipping to your door
Cons
- New program with a short independent track record
- No brand-name (Wegovy/Zepbound) pathway
Cash-pay users who want the cheapest tirzepatide from a US-licensed program
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Trimi at $99/month. Semaglutide $99/mo; tirzepatide $125/mo — cheapest tirzepatide floor we track.
ShedRx has the edge with a 8.8 rating.
Trimi focuses on compounded medications at a lower price point.
Compare their support: ShedRx offers licensed physicians, health coaching, supplement guidance, while Trimi provides us-licensed clinicians, telehealth consults, dose adjustments.
ShedRx at $199/month may offer features that justify the premium.
Frequently Asked Questions
Is ShedRx better than Trimi?
ShedRx has a 8.8 rating while Trimi has a 8.3 rating. The better choice depends on your priorities — ShedRx is best for users who want multiple medication delivery forms and a money-back weight loss guarantee, while Trimi is best for cash-pay users who want the cheapest tirzepatide from a us-licensed program.
How much does ShedRx cost compared to Trimi?
ShedRx starts at $199/month ($199/mo semaglutide starting dose, up to $299/mo at higher doses. brand pathway $99/mo + pharmacy cost.), while Trimi starts at $99/month (semaglutide $99/mo; tirzepatide $125/mo — cheapest tirzepatide floor we track).
Do ShedRx and Trimi accept insurance?
ShedRx does not accept insurance. Trimi does not accept insurance.
Which GLP-1 medications does ShedRx offer vs Trimi?
ShedRx offers Compounded Semaglutide, Compounded Tirzepatide, Wegovy, Zepbound. Trimi offers Compounded Semaglutide, Compounded Tirzepatide.
Can I cancel ShedRx or Trimi at any time?
ShedRx allows cancel anytime. Trimi also allows cancel anytime.
Are ShedRx and Trimi available in my state?
ShedRx is available in all 50 states. Trimi is available in 47 states.
Not sure ShedRx or Trimi is right for you?
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