ShedRx vs SynergyRx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of ShedRx and SynergyRx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend ShedRx
Between these two providers, ShedRx is our pick for most users. It offers a higher overall rating (8.8 vs 5.6), more affordable pricing, availability in all 50 states. That said, SynergyRx may be the better fit if you are looking for users who want predictable bundled pricing with 24/7 support access.
ShedRx scores 8.8/10 in our independent evaluation at $159/month, while SynergyRx scores 5.6/10 at $200/month. Both programs include a licensed physician consultation and ship medication directly to your door. ShedRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | ShedRx | SynergyRx |
|---|---|---|
| Monthly Price | $159 | $200 |
| Rating | 8.8 / 10 | 5.6 / 10 |
| Medication Type | Brand & Compounded | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | Licensed physicians, health coaching, supplement guidance | Licensed providers, 24/7 messaging, unlimited check-ins |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
ShedRx: Detailed Look
ShedRx
150K+ members with 5 medication forms — injections, oral drops, lozenges, tablets, and pills
Pros
- Most delivery forms of any provider: injections, oral drops, lozenges, tablets, and pills
- 120-day guarantee: lose 5% (or reach your goal weight) or your money back — first-time GLP-1 users, coaching and check-in conditions apply
- Both compounded and brand-name options (Wegovy, Zepbound)
- 150,000+ members, health coaching and supplements included
Cons
- 2-month minimum on every plan; the $159 rate needs a 12-month commitment ($199 month-to-month)
- Recurring Trustpilot complaints about cancellations, reaching support and unexpected charges
Users who want multiple medication delivery forms and a money-back weight loss guarantee
SynergyRx: Detailed Look
SynergyRx
Bundled GLP-1 programs with 24/7 support and no hidden fees
Pros
- All-inclusive bundled pricing — no fees for messaging or adjustments
- Free expedited shipping on all orders
- 24/7 support access with unlimited messaging
- Partners with multiple certified pharmacies for reliability
Cons
- Starting price of $200/mo is mid-range for compounded semaglutide
- May not be available in all 50 states
Users who want predictable bundled pricing with 24/7 support access
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with ShedRx at $159/month. Now trading as Shed (tryshed.com). Compounded semaglutide from $159/mo (12-month plan; $179 6-month, $199 monthly) and tirzepatide from $239/mo ($269 / $299). Oral options: lozenges from $199, liquid drops from $229, semaglutide tablets from $299. Brand pathway: Wegovy pill $149 / pen $199, Zepbound $349, Foundayo $149 — medication only, plus a $125/mo Shed membership. Every plan carries a 2-month minimum..
ShedRx has the edge with a 8.8 rating.
Compare their support: ShedRx offers licensed physicians, health coaching, supplement guidance, while SynergyRx provides licensed providers, 24/7 messaging, unlimited check-ins.
SynergyRx at $200/month may offer features that justify the premium.
Frequently Asked Questions
Is ShedRx better than SynergyRx?
ShedRx has a 8.8 rating while SynergyRx has a 5.6 rating. The better choice depends on your priorities — ShedRx is best for users who want multiple medication delivery forms and a money-back weight loss guarantee, while SynergyRx is best for users who want predictable bundled pricing with 24/7 support access.
How much does ShedRx cost compared to SynergyRx?
ShedRx starts at $159/month (now trading as shed (tryshed.com). compounded semaglutide from $159/mo (12-month plan; $179 6-month, $199 monthly) and tirzepatide from $239/mo ($269 / $299). oral options: lozenges from $199, liquid drops from $229, semaglutide tablets from $299. brand pathway: wegovy pill $149 / pen $199, zepbound $349, foundayo $149 — medication only, plus a $125/mo shed membership. every plan carries a 2-month minimum.), while SynergyRx starts at $200/month ($200/mo semaglutide, $299-347/mo tirzepatide).
Do ShedRx and SynergyRx accept insurance?
ShedRx does not accept insurance. SynergyRx does not accept insurance.
Which GLP-1 medications does ShedRx offer vs SynergyRx?
ShedRx offers Compounded Semaglutide, Compounded Tirzepatide, Wegovy, Zepbound, Foundayo (oral orforglipron). SynergyRx offers Compounded Semaglutide, Compounded Tirzepatide, Ozempic, Wegovy, Mounjaro.
Can I cancel ShedRx or SynergyRx at any time?
ShedRx may have cancellation restrictions. SynergyRx also allows cancel anytime.
Are ShedRx and SynergyRx available in my state?
ShedRx is available in all 50 states. SynergyRx is available in 45 states.
Not sure ShedRx or SynergyRx is right for you?
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