TMates vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of TMates and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend TMates
Between these two providers, TMates is our pick for most users. It offers a higher overall rating (7.8 vs 7.2), more affordable pricing. That said, Sesame Care may be the better fit if you are looking for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
TMates scores 7.8/10 in our independent evaluation at $158/month, while Sesame Care scores 7.2/10 at $208/month. Both programs include a licensed physician consultation and ship medication directly to your door. TMates accepts insurance, which can significantly reduce costs. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | TMates | Sesame Care |
|---|---|---|
| Monthly Price | $158 | $208 |
| Rating | 7.8 / 10 | 7.2 / 10 |
| Medication Type | Compounded Only | Brand-Name Only |
| Insurance Accepted | Yes | Yes |
| States Available | 45 states | All 50 states |
| Consultation Fee | Included | $59/mo care subscription (12-month commitment) |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed providers, SMS coaching, digital check-ins | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
TMates: Detailed Look
TMates
GLP-1 weight loss program that accepts major insurance plans
Pros
- One of the few GLP-1 providers that accepts major insurance
- Flat-rate pricing includes meds, consults, coaching, and delivery
- 24/7 SMS-based coaching and digital check-ins
- Phentermine option for non-GLP-1 candidates
Cons
- Relatively newer platform with limited independent reviews
- Full program details require enrollment to verify
Users with insurance who want a coached GLP-1 program with multiple medication options
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent per-visit pricing with no subscriptions
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
People who specifically want brand-name FDA-approved GLP-1s and will commit to a year of care — not the cheapest route, and no compounded option
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with TMates at $158/month. Compounded semaglutide from $158/mo and tirzepatide from $167/mo, all-inclusive (visits, coaching, medication). Brand Zepbound/Wegovy pathway at $99/mo with insurance coverage..
TMates has the edge with a 7.8 rating.
Choose Sesame Care which exclusively prescribes brand-name medications.
TMates focuses on compounded medications at a lower price point.
Compare their support: TMates offers licensed providers, sms coaching, digital check-ins, while Sesame Care provides licensed physicians, per-visit model.
Sesame Care at $208/month may offer features that justify the premium.
Frequently Asked Questions
Is TMates better than Sesame Care?
TMates has a 7.8 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — TMates is best for users with insurance who want a coached glp-1 program with multiple medication options, while Sesame Care is best for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
How much does TMates cost compared to Sesame Care?
TMates starts at $158/month (compounded semaglutide from $158/mo and tirzepatide from $167/mo, all-inclusive (visits, coaching, medication). brand zepbound/wegovy pathway at $99/mo with insurance coverage.), while Sesame Care starts at $208/month (sesame has moved to a "success by sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — wegovy from $149/mo brings the all-in to roughly $208/mo, and zepbound from $299/mo to roughly $358/mo. brand-name fda-approved medication only; sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. verified august 31, 2026.).
Do TMates and Sesame Care accept insurance?
TMates accepts insurance. Sesame Care accepts insurance.
Which GLP-1 medications does TMates offer vs Sesame Care?
TMates offers Compounded Semaglutide, Compounded Tirzepatide, Phentermine. Sesame Care offers Wegovy, Wegovy HD, Wegovy (oral), Zepbound, Zepbound KwikPen, Foundayo.
Can I cancel TMates or Sesame Care at any time?
TMates allows cancel anytime. Sesame Care also allows cancel anytime.
Are TMates and Sesame Care available in my state?
TMates is available in 45 states. Sesame Care is available in all 50 states.
Not sure TMates or Sesame Care is right for you?
Answer 6 questions and we'll match you with the best program for your budget and goals.