SynergyRx vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of SynergyRx and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Sesame Care
Between these two providers, Sesame Care is our pick for most users. It offers a higher overall rating (7.2 vs 5.6), availability in all 50 states, insurance acceptance. That said, SynergyRx may be the better fit if you are looking for users who want predictable bundled pricing with 24/7 support access.
Sesame Care scores 7.2/10 in our independent evaluation at $208/month, while SynergyRx scores 5.6/10 at $200/month. Both programs include a licensed physician consultation and ship medication directly to your door. Sesame Care accepts insurance, which can significantly reduce costs. Sesame Care also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | SynergyRx | Sesame Care |
|---|---|---|
| Monthly Price | $200 | $208 |
| Rating | 5.6 / 10 | 7.2 / 10 |
| Medication Type | Brand & Compounded | Brand-Name Only |
| Insurance Accepted | No | Yes |
| States Available | 45 states | All 50 states |
| Consultation Fee | Included | $59/mo care subscription (12-month commitment) |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed providers, 24/7 messaging, unlimited check-ins | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
SynergyRx: Detailed Look
SynergyRx
Bundled GLP-1 programs with 24/7 support and no hidden fees
Pros
- All-inclusive bundled pricing — no fees for messaging or adjustments
- Free expedited shipping on all orders
- 24/7 support access with unlimited messaging
- Partners with multiple certified pharmacies for reliability
Cons
- Starting price of $200/mo is mid-range for compounded semaglutide
- May not be available in all 50 states
Users who want predictable bundled pricing with 24/7 support access
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent pricing: a $59/mo care subscription plus the manufacturer's own medication price
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
People who specifically want brand-name FDA-approved GLP-1s and will commit to a year of care — not the cheapest route, and no compounded option
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with SynergyRx at $200/month. $200/mo semaglutide, $299-347/mo tirzepatide.
Sesame Care has the edge with a 7.2 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Choose Sesame Care which exclusively prescribes brand-name medications.
Compare their support: SynergyRx offers licensed providers, 24/7 messaging, unlimited check-ins, while Sesame Care provides licensed physicians, per-visit model.
Sesame Care at $208/month may offer features that justify the premium.
Frequently Asked Questions
Is SynergyRx better than Sesame Care?
SynergyRx has a 5.6 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — SynergyRx is best for users who want predictable bundled pricing with 24/7 support access, while Sesame Care is best for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
How much does SynergyRx cost compared to Sesame Care?
SynergyRx starts at $200/month ($200/mo semaglutide, $299-347/mo tirzepatide), while Sesame Care starts at $208/month (sesame has moved to a "success by sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — wegovy from $149/mo brings the all-in to roughly $208/mo, and zepbound from $299/mo to roughly $358/mo. brand-name fda-approved medication only; sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. verified august 31, 2026.).
Do SynergyRx and Sesame Care accept insurance?
SynergyRx does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does SynergyRx offer vs Sesame Care?
SynergyRx offers Compounded Semaglutide, Compounded Tirzepatide, Ozempic, Wegovy, Mounjaro. Sesame Care offers Wegovy, Wegovy HD, Wegovy (oral), Zepbound, Zepbound KwikPen, Foundayo.
Can I cancel SynergyRx or Sesame Care at any time?
SynergyRx allows cancel anytime. Sesame Care also allows cancel anytime.
Are SynergyRx and Sesame Care available in my state?
SynergyRx is available in 45 states. Sesame Care is available in all 50 states.
Not sure SynergyRx or Sesame Care is right for you?
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