Sesame Care vs SynergyRx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Sesame Care and SynergyRx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Sesame Care
Between these two providers, Sesame Care is our pick for most users. It offers a higher overall rating (7.2 vs 5.6), availability in all 50 states, insurance acceptance. That said, SynergyRx may be the better fit if you are looking for users who want predictable bundled pricing with 24/7 support access.
Sesame Care scores 7.2/10 in our independent evaluation at $225/month, while SynergyRx scores 5.6/10 at $200/month. Both programs include a licensed physician consultation and ship medication directly to your door. Sesame Care accepts insurance, which can significantly reduce costs. Sesame Care also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Sesame Care | SynergyRx |
|---|---|---|
| Monthly Price | $225 | $200 |
| Rating | 7.2 / 10 | 5.6 / 10 |
| Medication Type | Brand & Compounded | Brand & Compounded |
| Insurance Accepted | Yes | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | $25-75 | Included |
| Shipping | Paid | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, per-visit model | Licensed providers, 24/7 messaging, unlimited check-ins |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent per-visit pricing with no subscriptions
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
Users with insurance who want cheap doctor visits — medication costs are separate and not included
SynergyRx: Detailed Look
SynergyRx
Bundled GLP-1 programs with 24/7 support and no hidden fees
Pros
- All-inclusive bundled pricing — no fees for messaging or adjustments
- Free expedited shipping on all orders
- 24/7 support access with unlimited messaging
- Partners with multiple certified pharmacies for reliability
Cons
- Starting price of $200/mo is mid-range for compounded semaglutide
- May not be available in all 50 states
Users who want predictable bundled pricing with 24/7 support access
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with SynergyRx at $200/month. $200/mo semaglutide, $299-347/mo tirzepatide.
Sesame Care has the edge with a 7.2 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Compare their support: Sesame Care offers licensed physicians, per-visit model, while SynergyRx provides licensed providers, 24/7 messaging, unlimited check-ins.
Sesame Care at $225/month may offer features that justify the premium.
Frequently Asked Questions
Is Sesame Care better than SynergyRx?
Sesame Care has a 7.2 rating while SynergyRx has a 5.6 rating. The better choice depends on your priorities — Sesame Care is best for users with insurance who want cheap doctor visits — medication costs are separate and not included, while SynergyRx is best for users who want predictable bundled pricing with 24/7 support access.
How much does Sesame Care cost compared to SynergyRx?
Sesame Care starts at $225/month ($25-75 per visit + medication at pharmacy prices ($200-1,400/mo). total starting cost ~$225/mo with insurance savings cards. medication not included in visit fee.), while SynergyRx starts at $200/month ($200/mo semaglutide, $299-347/mo tirzepatide).
Do Sesame Care and SynergyRx accept insurance?
Sesame Care accepts insurance. SynergyRx does not accept insurance.
Which GLP-1 medications does Sesame Care offer vs SynergyRx?
Sesame Care offers Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus. SynergyRx offers Compounded Semaglutide, Compounded Tirzepatide, Ozempic, Wegovy, Mounjaro.
Can I cancel Sesame Care or SynergyRx at any time?
Sesame Care allows cancel anytime. SynergyRx also allows cancel anytime.
Are Sesame Care and SynergyRx available in my state?
Sesame Care is available in all 50 states. SynergyRx is available in 45 states.
Not sure Sesame Care or SynergyRx is right for you?
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