Yucca Health vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Yucca Health and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (8.9 vs 7.6), more affordable pricing. That said, PlexusDx may be the better fit if you are looking for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
Yucca Health scores 8.9/10 in our evaluation at $125/month, while PlexusDx scores 7.6/10 at $149/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Yucca Health | PlexusDx |
|---|---|---|
| Monthly Price | $125 | $149 |
| Rating | 8.9 / 10 | 7.6 / 10 |
| Medication Type | Compounded Only | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | Licensed U.S. physicians (Dr. Wasef, Dr. Sakla), provider-guided care, 24hr review | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Yucca Health: Detailed Look
Yucca Health
LegitScript-certified GLP-1 provider with named physicians and BNPL financing
Pros
- LegitScript certified — pharmacy and telehealth verified
- 4.6/5 Trustpilot rating from 1,000+ verified patient reviews
- Named physicians: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Buy now, pay later via Klarna, Affirm, and Afterpay
Cons
- Best pricing requires 6-month commitment
- Compounded medications only — no brand-name options
Users who want a LegitScript-certified provider with verified patient reviews and flexible financing
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Yucca Health at $125/month. $125/mo semaglutide and $225/mo tirzepatide on the advertised 6-month plan ($750 / $1,350 total); month-to-month runs $146 / $258. Klarna/Affirm/Afterpay available..
Yucca Health has the edge with a 8.9 rating.
Compare their support: Yucca Health offers licensed u.s. physicians (dr. wasef, dr. sakla), provider-guided care, 24hr review, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
PlexusDx at $149/month may offer features that justify the premium.
Frequently Asked Questions
Is Yucca Health better than PlexusDx?
Yucca Health has a 8.9 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Yucca Health is best for users who want a legitscript-certified provider with verified patient reviews and flexible financing, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Yucca Health cost compared to PlexusDx?
Yucca Health starts at $125/month ($125/mo semaglutide and $225/mo tirzepatide on the advertised 6-month plan ($750 / $1,350 total); month-to-month runs $146 / $258. klarna/affirm/afterpay available.), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Yucca Health and PlexusDx accept insurance?
Yucca Health does not accept insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Yucca Health offer vs PlexusDx?
Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+. PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Yucca Health or PlexusDx at any time?
Yucca Health may have cancellation restrictions. PlexusDx also allows cancel anytime.
Are Yucca Health and PlexusDx available in my state?
Yucca Health is available in all 50 states. PlexusDx is available in all 50 states.
Not sure Yucca Health or PlexusDx is right for you?
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