Willow vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Willow and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend PlexusDx
Between these two providers, PlexusDx is our pick for most users. It offers a higher overall rating (7.6 vs 6.9), more affordable pricing, availability in all 50 states. That said, Willow may be the better fit if you are looking for women who want a tablet option and 24/7 support and will pay a premium for it.
PlexusDx scores 7.6/10 in our evaluation at $149/month, while Willow scores 6.9/10 at $299/month. Both programs include a licensed physician consultation and ship medication directly to your door. PlexusDx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Willow | PlexusDx |
|---|---|---|
| Monthly Price | $299 | $149 |
| Rating | 6.9 / 10 | 7.6 / 10 |
| Medication Type | Compounded Only | Compounded Only |
| Insurance Accepted | No | No |
| States Available | 38 states | All 50 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, unlimited doctor access, 24/7 online care team | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Willow: Detailed Look
Willow
Personalized GLP-1 weight loss with ongoing clinical support
Pros
- Injectable or dissolving-tablet semaglutide and tirzepatide at the same price
- Unlimited doctor access plus a 24/7 online care team
- Displays a LegitScript certification seal; HSA/FSA eligible
- Free shipping; cancel anytime (full refund if you cancel before the prescription goes to the pharmacy)
Cons
- $299/mo semaglutide and $399/mo tirzepatide — among the most expensive compounded plans we track, with no multi-month discount
- Serves 38 states — not available in AL, AK, AR, DE, KS, LA, MS, ND, RI, SD, UT or WV
- Newer platform — fewer long-term patient reviews available
Women who want a tablet option and 24/7 support and will pay a premium for it
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with PlexusDx at $149/month. Compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. Oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose Microdose GLP-1 program is $129/mo. Each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. The site does not say whether the 3- and 6-month tiers are billed up front. An optional GLP-1 & Peptide Pathways genetic test is offered for $99 (list $298) after the first program order. Verified October 3, 2026..
PlexusDx has the edge with a 7.6 rating.
Compare their support: Willow offers licensed physicians, unlimited doctor access, 24/7 online care team, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
Willow at $299/month may offer features that justify the premium.
Frequently Asked Questions
Is Willow better than PlexusDx?
Willow has a 6.9 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Willow is best for women who want a tablet option and 24/7 support and will pay a premium for it, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Willow cost compared to PlexusDx?
Willow starts at $299/month (compounded semaglutide $299/mo and tirzepatide $399/mo, billed month-to-month with no plan tiers ('one time for $299 / subscribe for $299'); the same prices apply to willow's semaglutide and tirzepatide dissolving tablets. hsa/fsa eligible, free 2-day shipping, medical evaluation included. read on startwillow.com product pages september 18, 2026 — the previous $160 'starting price' matched nothing on the site.), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Willow and PlexusDx accept insurance?
Willow does not accept insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Willow offer vs PlexusDx?
Willow offers Compounded Semaglutide (Injectable), Compounded Tirzepatide (Injectable), Compounded Semaglutide (Tablets), Compounded Tirzepatide (Tablets). PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Willow or PlexusDx at any time?
Willow allows cancel anytime. PlexusDx also allows cancel anytime.
Are Willow and PlexusDx available in my state?
Willow is available in 38 states. PlexusDx is available in all 50 states.
Not sure Willow or PlexusDx is right for you?
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