Sesame Care vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Sesame Care and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend PlexusDx
Between these two providers, PlexusDx is our pick for most users. It offers a higher overall rating (7.6 vs 7.2), more affordable pricing. That said, Sesame Care may be the better fit if you are looking for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
PlexusDx scores 7.6/10 in our evaluation at $149/month, while Sesame Care scores 7.2/10 at $208/month. Both programs include a licensed physician consultation and ship medication directly to your door. PlexusDx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Sesame Care | PlexusDx |
|---|---|---|
| Monthly Price | $208 | $149 |
| Rating | 7.2 / 10 | 7.6 / 10 |
| Medication Type | Brand-Name Only | Compounded Only |
| Insurance Accepted | Yes | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | $59/mo care subscription (12-month commitment) | Included |
| Shipping | Paid | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, per-visit model | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent pricing: a $59/mo care subscription plus the manufacturer's own medication price
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
People who specifically want brand-name FDA-approved GLP-1s and will commit to a year of care — not the cheapest route, and no compounded option
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with PlexusDx at $149/month. Compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. Oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose Microdose GLP-1 program is $129/mo. Each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. The site does not say whether the 3- and 6-month tiers are billed up front. An optional GLP-1 & Peptide Pathways genetic test is offered for $99 (list $298) after the first program order. Verified October 3, 2026..
PlexusDx has the edge with a 7.6 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Choose Sesame Care which exclusively prescribes brand-name medications.
PlexusDx focuses on compounded medications at a lower price point.
Compare their support: Sesame Care offers licensed physicians, per-visit model, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
Sesame Care at $208/month may offer features that justify the premium.
Frequently Asked Questions
Is Sesame Care better than PlexusDx?
Sesame Care has a 7.2 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Sesame Care is best for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Sesame Care cost compared to PlexusDx?
Sesame Care starts at $208/month (sesame has moved to a "success by sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — wegovy from $149/mo brings the all-in to roughly $208/mo, and zepbound from $299/mo to roughly $358/mo. brand-name fda-approved medication only; sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. verified august 31, 2026.), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Sesame Care and PlexusDx accept insurance?
Sesame Care accepts insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Sesame Care offer vs PlexusDx?
Sesame Care offers Wegovy, Wegovy HD, Wegovy (oral), Zepbound, Zepbound KwikPen, Foundayo. PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Sesame Care or PlexusDx at any time?
Sesame Care allows cancel anytime. PlexusDx also allows cancel anytime.
Are Sesame Care and PlexusDx available in my state?
Sesame Care is available in all 50 states. PlexusDx is available in all 50 states.
Not sure Sesame Care or PlexusDx is right for you?
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