Oak Longevity vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Oak Longevity and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Oak Longevity
Between these two providers, Oak Longevity is our pick for most users. It offers a higher overall rating (8.9 vs 7.6), more affordable pricing. That said, PlexusDx may be the better fit if you are looking for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
Oak Longevity scores 8.9/10 in our evaluation at $119/month, while PlexusDx scores 7.6/10 at $149/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Oak Longevity | PlexusDx |
|---|---|---|
| Monthly Price | $119 | $149 |
| Rating | 8.9 / 10 | 7.6 / 10 |
| Medication Type | Compounded Only | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified physicians, free health coaching, responsive care team | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Oak Longevity: Detailed Look
Oak Longevity
Affordable compounded semaglutide from $119/mo with free shipping and health coaching
Pros
- Compounded semaglutide from $119/mo and tirzepatide from $185/mo (12-month plan)
- Free shipping + free health coaching included
- No membership fee — the plan price includes the medication
- Same-day approval with 10,000+ satisfied patients
Cons
- Compounded medications only — no brand-name options
- Newer platform with limited independent reviews
Budget-conscious users who want the lowest price with health coaching and no membership fees
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Oak Longevity at $119/month. Compounded semaglutide from $119/mo and compounded tirzepatide from $185/mo, both on a 12-month plan — the headline on Oak's own /semaglutide and /tirzepatide product pages (read September 25, 2026: 'Compounded prices shown on 12-month plans'; shorter plans are available and the exact price is confirmed before checkout, but the shorter-plan prices are not published). The homepage also says 'GLP-1 Treatments for weight loss from $89/mo' without naming the product; we rank on the product-page figures. Until September 2026 Oak advertised $167/mo semaglutide and published no tirzepatide price..
Oak Longevity has the edge with a 8.9 rating.
Compare their support: Oak Longevity offers board-certified physicians, free health coaching, responsive care team, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
PlexusDx at $149/month may offer features that justify the premium.
Frequently Asked Questions
Is Oak Longevity better than PlexusDx?
Oak Longevity has a 8.9 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Oak Longevity is best for budget-conscious users who want the lowest price with health coaching and no membership fees, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Oak Longevity cost compared to PlexusDx?
Oak Longevity starts at $119/month (compounded semaglutide from $119/mo and compounded tirzepatide from $185/mo, both on a 12-month plan — the headline on oak's own /semaglutide and /tirzepatide product pages (read september 25, 2026: 'compounded prices shown on 12-month plans'; shorter plans are available and the exact price is confirmed before checkout, but the shorter-plan prices are not published). the homepage also says 'glp-1 treatments for weight loss from $89/mo' without naming the product; we rank on the product-page figures. until september 2026 oak advertised $167/mo semaglutide and published no tirzepatide price.), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Oak Longevity and PlexusDx accept insurance?
Oak Longevity does not accept insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Oak Longevity offer vs PlexusDx?
Oak Longevity offers Compounded Semaglutide, Compounded Tirzepatide. PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Oak Longevity or PlexusDx at any time?
Oak Longevity allows cancel anytime. PlexusDx also allows cancel anytime.
Are Oak Longevity and PlexusDx available in my state?
Oak Longevity is available in all 50 states. PlexusDx is available in all 50 states.
Not sure Oak Longevity or PlexusDx is right for you?
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