Fridays vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Fridays and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend PlexusDx
Between these two providers, PlexusDx is our pick for most users. It offers a higher overall rating (7.6 vs 6.8), more affordable pricing, availability in all 50 states. That said, Fridays may be the better fit if you are looking for users who want a holistic program with coaching, nutrition support, and flexible pricing.
PlexusDx scores 7.6/10 in our evaluation at $149/month, while Fridays scores 6.8/10 at $249/month. Both programs include a licensed physician consultation and ship medication directly to your door. PlexusDx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Fridays | PlexusDx |
|---|---|---|
| Monthly Price | $249 | $149 |
| Rating | 6.8 / 10 | 7.6 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | Yes | No |
| States Available | 49 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed providers, health coaching, nutrition support | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Fridays: Detailed Look
Fridays
Holistic GLP-1 weight loss with coaching, nutrition, and clinical support
Pros
- Plans include provider visits, coaching, and nutrition support
- 12-month plan drops price to as low as $150/month
- Accepts insurance for brand-name medications
- HSA/FSA accepted with itemized receipts
Cons
- Not available in Louisiana (49 states only)
- 12-month plan requires upfront payment for best discount
Users who want a holistic program with coaching, nutrition support, and flexible pricing
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with PlexusDx at $149/month. Compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. Oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose Microdose GLP-1 program is $129/mo. Each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. The site does not say whether the 3- and 6-month tiers are billed up front. An optional GLP-1 & Peptide Pathways genetic test is offered for $99 (list $298) after the first program order. Verified October 3, 2026..
PlexusDx has the edge with a 7.6 rating.
Fridays accepts insurance, which can significantly reduce your out-of-pocket cost.
PlexusDx focuses on compounded medications at a lower price point.
Compare their support: Fridays offers licensed providers, health coaching, nutrition support, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
Fridays at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Fridays better than PlexusDx?
Fridays has a 6.8 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Fridays is best for users who want a holistic program with coaching, nutrition support, and flexible pricing, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Fridays cost compared to PlexusDx?
Fridays starts at $249/month (as low as $150/mo on 12-month plan), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Fridays and PlexusDx accept insurance?
Fridays accepts insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Fridays offer vs PlexusDx?
Fridays offers Compounded Semaglutide, Compounded Tirzepatide, Brand-name GLP-1s (with insurance). PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Fridays or PlexusDx at any time?
Fridays allows cancel anytime. PlexusDx also allows cancel anytime.
Are Fridays and PlexusDx available in my state?
Fridays is available in 49 states. PlexusDx is available in all 50 states.
Not sure Fridays or PlexusDx is right for you?
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