Enhance MD vs Yucca Health: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and Yucca Health to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers a higher overall rating (8.3 vs 7.7), more affordable pricing, availability in all 50 states, both brand-name and compounded medication options. That said, Yucca Health may be the better fit if you are looking for price-sensitive users willing to commit to a 6-month plan for the lowest per-month cost.
Side-by-Side Comparison
| Feature | Enhance MD | Yucca Health |
|---|---|---|
| Monthly Price | $115 | $146 |
| Rating | 8.3 / 10 | 7.7 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | Included | Free |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | No |
| Medical Support | Board-certified physicians | Licensed providers, asynchronous review |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated March 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Yucca Health: Detailed Look
Yucca Health
Competitive GLP-1 pricing with fast 2-day shipping and flexible payment
Pros
- Competitive pricing on 6-month plans
- Fast UPS 2-Day Air shipping included
- Flexible payment via Affirm, Klarna, and Afterpay
- No live doctor visit required — fully asynchronous review
Cons
- Pricing only revealed after completing intake form
- Does not provide HSA/FSA receipts for reimbursement
Price-sensitive users willing to commit to a 6-month plan for the lowest per-month cost
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Enhance MD at $115/month. $115 standard; $250 with NAD+ therapy.
Enhance MD has the edge with a 8.3 rating.
Yucca Health focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified physicians, while Yucca Health provides licensed providers, asynchronous review.
Yucca Health at $146/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Yucca Health?
Enhance MD has a 8.3 rating while Yucca Health has a 7.7 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while Yucca Health is best for price-sensitive users willing to commit to a 6-month plan for the lowest per-month cost.
How much does Enhance MD cost compared to Yucca Health?
Enhance MD starts at $115/month ($115 standard; $250 with nad+ therapy), while Yucca Health starts at $146/month ($146/mo semaglutide on 6-month plan, $258/mo tirzepatide).
Do Enhance MD and Yucca Health accept insurance?
Enhance MD does not accept insurance. Yucca Health does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs Yucca Health?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+.
Can I cancel Enhance MD or Yucca Health at any time?
Enhance MD allows cancel anytime. Yucca Health may have cancellation restrictions.
Are Enhance MD and Yucca Health available in my state?
Enhance MD is available in all 50 states. Yucca Health is available in 45 states.