Enhance MD vs Yucca Health: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and Yucca Health to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (9.2 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
Yucca Health scores 9.2/10 in our independent evaluation at $146/month, while Enhance MD scores 8.3/10 at $249/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | Yucca Health |
|---|---|---|
| Monthly Price | $249 | $146 |
| Rating | 8.3 / 10 | 9.2 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | Free |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | No |
| Medical Support | Board-certified physicians | Licensed U.S. physicians (Dr. Wasef, Dr. Sakla), provider-guided care, 24hr review |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Yucca Health: Detailed Look
Yucca Health
LegitScript-certified GLP-1 provider with named physicians and BNPL financing
Pros
- LegitScript certified — pharmacy and telehealth verified
- 4.6/5 Trustpilot rating from 1,000+ verified patient reviews
- Named physicians: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Buy now, pay later via Klarna, Affirm, and Afterpay
Cons
- Best pricing requires 6-month commitment
- Compounded medications only — no brand-name options
Users who want a LegitScript-certified provider with verified patient reviews and flexible financing
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Yucca Health at $146/month. $146/mo semaglutide on 6-month plan, $258/mo tirzepatide. Klarna/Affirm/Afterpay available..
Yucca Health has the edge with a 9.2 rating.
Yucca Health focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified physicians, while Yucca Health provides licensed u.s. physicians (dr. wasef, dr. sakla), provider-guided care, 24hr review.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Yucca Health?
Enhance MD has a 8.3 rating while Yucca Health has a 9.2 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while Yucca Health is best for users who want a legitscript-certified provider with verified patient reviews and flexible financing.
How much does Enhance MD cost compared to Yucca Health?
Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%), while Yucca Health starts at $146/month ($146/mo semaglutide on 6-month plan, $258/mo tirzepatide. klarna/affirm/afterpay available.).
Do Enhance MD and Yucca Health accept insurance?
Enhance MD does not accept insurance. Yucca Health does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs Yucca Health?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+.
Can I cancel Enhance MD or Yucca Health at any time?
Enhance MD allows cancel anytime. Yucca Health may have cancellation restrictions.
Are Enhance MD and Yucca Health available in my state?
Enhance MD is available in all 50 states. Yucca Health is available in all 50 states.