Yucca Health vs Enhance MD: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Yucca Health and Enhance MD to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (9.2 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
Yucca Health scores 9.2/10 in our independent evaluation at $146/month, while Enhance MD scores 8.3/10 at $249/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Yucca Health | Enhance MD |
|---|---|---|
| Monthly Price | $146 | $249 |
| Rating | 9.2 / 10 | 8.3 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | Licensed U.S. physicians (Dr. Wasef, Dr. Sakla), provider-guided care, 24hr review | Board-certified physicians |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Yucca Health: Detailed Look
Yucca Health
LegitScript-certified GLP-1 provider with named physicians and BNPL financing
Pros
- LegitScript certified — pharmacy and telehealth verified
- 4.6/5 Trustpilot rating from 1,000+ verified patient reviews
- Named physicians: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Buy now, pay later via Klarna, Affirm, and Afterpay
Cons
- Best pricing requires 6-month commitment
- Compounded medications only — no brand-name options
Users who want a LegitScript-certified provider with verified patient reviews and flexible financing
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Yucca Health at $146/month. $146/mo semaglutide on 6-month plan, $258/mo tirzepatide. Klarna/Affirm/Afterpay available..
Yucca Health has the edge with a 9.2 rating.
Yucca Health focuses on compounded medications at a lower price point.
Compare their support: Yucca Health offers licensed u.s. physicians (dr. wasef, dr. sakla), provider-guided care, 24hr review, while Enhance MD provides board-certified physicians.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Yucca Health better than Enhance MD?
Yucca Health has a 9.2 rating while Enhance MD has a 8.3 rating. The better choice depends on your priorities — Yucca Health is best for users who want a legitscript-certified provider with verified patient reviews and flexible financing, while Enhance MD is best for budget-conscious users interested in combination therapies.
How much does Yucca Health cost compared to Enhance MD?
Yucca Health starts at $146/month ($146/mo semaglutide on 6-month plan, $258/mo tirzepatide. klarna/affirm/afterpay available.), while Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%).
Do Yucca Health and Enhance MD accept insurance?
Yucca Health does not accept insurance. Enhance MD does not accept insurance.
Which GLP-1 medications does Yucca Health offer vs Enhance MD?
Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+. Enhance MD offers Semaglutide, Tirzepatide, NAD+.
Can I cancel Yucca Health or Enhance MD at any time?
Yucca Health may have cancellation restrictions. Enhance MD also allows cancel anytime.
Are Yucca Health and Enhance MD available in my state?
Yucca Health is available in all 50 states. Enhance MD is available in all 50 states.
Not sure Yucca Health or Enhance MD is right for you?
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