Enhance MD vs Trimi: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and Trimi to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers availability in all 50 states, both brand-name and compounded medication options. That said, Trimi may be the better fit if you are looking for cash-pay users who want the cheapest tirzepatide from a us-licensed program.
Enhance MD scores 8.3/10 in our independent evaluation at $249/month, while Trimi scores 8.3/10 at $99/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | Trimi |
|---|---|---|
| Monthly Price | $249 | $99 |
| Rating | 8.3 / 10 | 8.3 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 47 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified physicians | US-licensed clinicians, telehealth consults, dose adjustments |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Trimi: Detailed Look
Trimi
Compounded GLP-1 from $99 with US-licensed clinicians
Pros
- Tirzepatide at $125/month — lowest tirzepatide price among verified programs
- Semaglutide at $99/month matches the market floor
- US-licensed clinicians with dose-adjustment support
- Free shipping to your door
Cons
- New program with a short independent track record
- No brand-name (Wegovy/Zepbound) pathway
Cash-pay users who want the cheapest tirzepatide from a US-licensed program
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Trimi at $99/month. Semaglutide $99/mo; tirzepatide $125/mo — cheapest tirzepatide floor we track.
Enhance MD has the edge with a 8.3 rating.
Trimi focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified physicians, while Trimi provides us-licensed clinicians, telehealth consults, dose adjustments.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Trimi?
Enhance MD has a 8.3 rating while Trimi has a 8.3 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while Trimi is best for cash-pay users who want the cheapest tirzepatide from a us-licensed program.
How much does Enhance MD cost compared to Trimi?
Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%), while Trimi starts at $99/month (semaglutide $99/mo; tirzepatide $125/mo — cheapest tirzepatide floor we track).
Do Enhance MD and Trimi accept insurance?
Enhance MD does not accept insurance. Trimi does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs Trimi?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Trimi offers Compounded Semaglutide, Compounded Tirzepatide.
Can I cancel Enhance MD or Trimi at any time?
Enhance MD allows cancel anytime. Trimi also allows cancel anytime.
Are Enhance MD and Trimi available in my state?
Enhance MD is available in all 50 states. Trimi is available in 47 states.
Not sure Enhance MD or Trimi is right for you?
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