Trimi vs Enhance MD: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Trimi and Enhance MD to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Trimi
Between these two providers, Trimi is our pick for most users. It offers a higher overall rating (9.2 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
Trimi scores 9.2/10 in our evaluation at $99/month, while Enhance MD scores 8.3/10 at $212/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Trimi | Enhance MD |
|---|---|---|
| Monthly Price | $99 | $212 |
| Rating | 9.2 / 10 | 8.3 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | 47 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | US-licensed clinicians, telehealth consults, dose adjustments | Board-certified physicians |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Trimi: Detailed Look
Trimi
Compounded GLP-1 from $99 with US-licensed clinicians
Pros
- Tirzepatide at $125/month — lowest tirzepatide price among verified programs
- Semaglutide at $99/month matches the market floor
- US-licensed clinicians with dose-adjustment support
- Free shipping to your door
Cons
- New program with a short independent track record
- No brand-name (Wegovy/Zepbound) pathway
Cash-pay users who want the cheapest tirzepatide from a US-licensed program
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Semaglutide $212/mo on the 12-month plan, same price at every dose, labs every 6 months included
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Trimi at $99/month. Semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. Same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. Verified September 6, 2026..
Trimi has the edge with a 9.2 rating.
Trimi focuses on compounded medications at a lower price point.
Compare their support: Trimi offers us-licensed clinicians, telehealth consults, dose adjustments, while Enhance MD provides board-certified physicians.
Enhance MD at $212/month may offer features that justify the premium.
Frequently Asked Questions
Is Trimi better than Enhance MD?
Trimi has a 9.2 rating while Enhance MD has a 8.3 rating. The better choice depends on your priorities — Trimi is best for cash-pay users who want the cheapest tirzepatide from a us-licensed program, while Enhance MD is best for budget-conscious users interested in combination therapies.
How much does Trimi cost compared to Enhance MD?
Trimi starts at $99/month (semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. verified september 6, 2026.), while Enhance MD starts at $212/month (semaglutide $212/mo and tirzepatide $280/mo on the 12-month plan (billed every 48 weeks); 6-month $224 / $296, 3-month $237 / $313, 1-month $249 / $329. same price at every dose, 'no hidden fees', provider care and labs every 6 months included. a labor day promotion advertises up to $150 off your first order only ($100 off multi-month, $50 off 1-month); the ongoing rates above are what you actually pay. a microdosing tirzepatide plan at $169/mo is capped at 1mg/week and is not a full-dose price. verified september 6, 2026.).
Do Trimi and Enhance MD accept insurance?
Trimi does not accept insurance. Enhance MD does not accept insurance.
Which GLP-1 medications does Trimi offer vs Enhance MD?
Trimi offers Compounded Semaglutide, Compounded Tirzepatide. Enhance MD offers Semaglutide, Tirzepatide, NAD+.
Can I cancel Trimi or Enhance MD at any time?
Trimi allows cancel anytime. Enhance MD also allows cancel anytime.
Are Trimi and Enhance MD available in my state?
Trimi is available in 47 states. Enhance MD is available in all 50 states.
Not sure Trimi or Enhance MD is right for you?
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