SkinnyRx vs Enhance MD: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of SkinnyRx and Enhance MD to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend SkinnyRx
Between these two providers, SkinnyRx is our pick for most users. It offers a higher overall rating (9.1 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
SkinnyRx scores 9.1/10 in our independent evaluation at $199/month, while Enhance MD scores 8.3/10 at $249/month. Both programs include a licensed physician consultation and ship medication directly to your door. SkinnyRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | SkinnyRx | Enhance MD |
|---|---|---|
| Monthly Price | $199 | $249 |
| Rating | 9.1 / 10 | 8.3 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | 48 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed U.S. physicians, 24-48hr prescription review | Board-certified physicians |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
SkinnyRx: Detailed Look
SkinnyRx
Fastest-growing GLP-1 provider — oral, sublingual, and injectable options with Affirm financing
Pros
- Three delivery forms: injectable, sublingual, and oral tablets
- Free overnight shipping from FDA-regulated U.S. pharmacies
- Month-to-month billing with no contracts
- 4.8/5 Trustpilot rating from thousands of verified reviews
Cons
- Cash-pay only — no insurance billing
- Compounded medications only — no brand-name options
Users who want multiple delivery forms (oral, sublingual, injectable) for their GLP-1
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with SkinnyRx at $199/month. $199/mo semaglutide, up to $349/mo for tirzepatide.
SkinnyRx has the edge with a 9.1 rating.
SkinnyRx focuses on compounded medications at a lower price point.
Compare their support: SkinnyRx offers licensed u.s. physicians, 24-48hr prescription review, while Enhance MD provides board-certified physicians.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is SkinnyRx better than Enhance MD?
SkinnyRx has a 9.1 rating while Enhance MD has a 8.3 rating. The better choice depends on your priorities — SkinnyRx is best for users who want multiple delivery forms (oral, sublingual, injectable) for their glp-1, while Enhance MD is best for budget-conscious users interested in combination therapies.
How much does SkinnyRx cost compared to Enhance MD?
SkinnyRx starts at $199/month ($199/mo semaglutide, up to $349/mo for tirzepatide), while Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%).
Do SkinnyRx and Enhance MD accept insurance?
SkinnyRx does not accept insurance. Enhance MD does not accept insurance.
Which GLP-1 medications does SkinnyRx offer vs Enhance MD?
SkinnyRx offers Compounded Semaglutide (Injectable), Compounded Semaglutide (Sublingual), Compounded Tirzepatide (Injectable), Compounded Tirzepatide (Tablets). Enhance MD offers Semaglutide, Tirzepatide, NAD+.
Can I cancel SkinnyRx or Enhance MD at any time?
SkinnyRx allows cancel anytime. Enhance MD also allows cancel anytime.
Are SkinnyRx and Enhance MD available in my state?
SkinnyRx is available in 48 states. Enhance MD is available in all 50 states.
Not sure SkinnyRx or Enhance MD is right for you?
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