Enhance MD vs SkinnyRx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and SkinnyRx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend SkinnyRx
Between these two providers, SkinnyRx is our pick for most users. It offers a higher overall rating (8.5 vs 8.3). That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
Side-by-Side Comparison
| Feature | Enhance MD | SkinnyRx |
|---|---|---|
| Monthly Price | $115 | $199 |
| Rating | 8.3 / 10 | 8.5 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | No |
| States Available | All 50 states | 48 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified physicians | Licensed U.S. physicians, 24-48hr prescription review |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated March 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
SkinnyRx: Detailed Look
SkinnyRx
Semaglutide and tirzepatide in injectable, oral, and sublingual forms
Pros
- Three delivery forms: injectable, sublingual, and oral tablets
- Free overnight shipping from FDA-regulated U.S. pharmacies
- Month-to-month billing with no contracts
- 4.8/5 Trustpilot rating from thousands of verified reviews
Cons
- Cash-pay only — no insurance billing
- Compounded medications only — no brand-name options
Users who want multiple delivery forms (oral, sublingual, injectable) for their GLP-1
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Enhance MD at $115/month. $115 standard; $250 with NAD+ therapy.
SkinnyRx has the edge with a 8.5 rating.
SkinnyRx focuses on compounded medications at a lower price point.
Compare their support: Enhance MD offers board-certified physicians, while SkinnyRx provides licensed u.s. physicians, 24-48hr prescription review.
SkinnyRx at $199/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than SkinnyRx?
Enhance MD has a 8.3 rating while SkinnyRx has a 8.5 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while SkinnyRx is best for users who want multiple delivery forms (oral, sublingual, injectable) for their glp-1.
How much does Enhance MD cost compared to SkinnyRx?
Enhance MD starts at $115/month ($115 standard; $250 with nad+ therapy), while SkinnyRx starts at $199/month ($199/mo semaglutide, up to $349/mo for tirzepatide).
Do Enhance MD and SkinnyRx accept insurance?
Enhance MD does not accept insurance. SkinnyRx does not accept insurance.
Which GLP-1 medications does Enhance MD offer vs SkinnyRx?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. SkinnyRx offers Compounded Semaglutide (Injectable), Compounded Semaglutide (Sublingual), Compounded Tirzepatide (Injectable), Compounded Tirzepatide (Tablets).
Can I cancel Enhance MD or SkinnyRx at any time?
Enhance MD allows cancel anytime. SkinnyRx also allows cancel anytime.
Are Enhance MD and SkinnyRx available in my state?
Enhance MD is available in all 50 states. SkinnyRx is available in 48 states.