ShedRx vs Enhance MD: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of ShedRx and Enhance MD to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend ShedRx
Between these two providers, ShedRx is our pick for most users. It offers a higher overall rating (8.8 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
ShedRx scores 8.8/10 in our evaluation at $159/month, while Enhance MD scores 8.3/10 at $212/month. Both programs include a licensed physician consultation and ship medication directly to your door. ShedRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | ShedRx | Enhance MD |
|---|---|---|
| Monthly Price | $159 | $212 |
| Rating | 8.8 / 10 | 8.3 / 10 |
| Medication Type | Brand & Compounded | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | Licensed physicians, health coaching, supplement guidance | Board-certified physicians |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
ShedRx: Detailed Look
ShedRx
150K+ members with 5 medication forms — injections, oral drops, lozenges, tablets, and pills
Pros
- Most delivery forms of any provider: injections, oral drops, lozenges, tablets, and pills
- 120-day guarantee: lose 5% (or reach your goal weight) or your money back — first-time GLP-1 users, coaching and check-in conditions apply
- Both compounded and brand-name options (Wegovy, Zepbound)
- 150,000+ members, health coaching and supplements included
Cons
- 2-month minimum on every plan; the $159 rate needs a 12-month commitment ($199 month-to-month)
- Recurring Trustpilot complaints about cancellations, reaching support and unexpected charges
Users who want multiple medication delivery forms and a money-back weight loss guarantee
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Semaglutide $212/mo on the 12-month plan, same price at every dose, labs every 6 months included
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with ShedRx at $159/month. Now trading as Shed (tryshed.com). Compounded semaglutide from $159/mo (12-month plan; $179 6-month, $199 monthly) and tirzepatide from $239/mo ($269 / $299). Oral options: lozenges from $199, liquid drops from $229, semaglutide tablets from $299. Brand pathway: Wegovy pill $149 / pen $199, Zepbound $349, Foundayo $149 — medication only, plus a $125/mo Shed membership. Every plan carries a 2-month minimum..
ShedRx has the edge with a 8.8 rating.
Compare their support: ShedRx offers licensed physicians, health coaching, supplement guidance, while Enhance MD provides board-certified physicians.
Enhance MD at $212/month may offer features that justify the premium.
Frequently Asked Questions
Is ShedRx better than Enhance MD?
ShedRx has a 8.8 rating while Enhance MD has a 8.3 rating. The better choice depends on your priorities — ShedRx is best for users who want multiple medication delivery forms and a money-back weight loss guarantee, while Enhance MD is best for budget-conscious users interested in combination therapies.
How much does ShedRx cost compared to Enhance MD?
ShedRx starts at $159/month (now trading as shed (tryshed.com). compounded semaglutide from $159/mo (12-month plan; $179 6-month, $199 monthly) and tirzepatide from $239/mo ($269 / $299). oral options: lozenges from $199, liquid drops from $229, semaglutide tablets from $299. brand pathway: wegovy pill $149 / pen $199, zepbound $349, foundayo $149 — medication only, plus a $125/mo shed membership. every plan carries a 2-month minimum.), while Enhance MD starts at $212/month (semaglutide $212/mo and tirzepatide $280/mo on the 12-month plan (billed every 48 weeks); 6-month $224 / $296, 3-month $237 / $313, 1-month $249 / $329. same price at every dose, 'no hidden fees', provider care and labs every 6 months included. a labor day promotion advertises up to $150 off your first order only ($100 off multi-month, $50 off 1-month); the ongoing rates above are what you actually pay. a microdosing tirzepatide plan at $169/mo is capped at 1mg/week and is not a full-dose price. verified september 6, 2026.).
Do ShedRx and Enhance MD accept insurance?
ShedRx does not accept insurance. Enhance MD does not accept insurance.
Which GLP-1 medications does ShedRx offer vs Enhance MD?
ShedRx offers Compounded Semaglutide, Compounded Tirzepatide, Wegovy, Zepbound, Foundayo (oral orforglipron). Enhance MD offers Semaglutide, Tirzepatide, NAD+.
Can I cancel ShedRx or Enhance MD at any time?
ShedRx may have cancellation restrictions. Enhance MD also allows cancel anytime.
Are ShedRx and Enhance MD available in my state?
ShedRx is available in all 50 states. Enhance MD is available in all 50 states.
Not sure ShedRx or Enhance MD is right for you?
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