Enhance MD vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers a higher overall rating (8.3 vs 7.2), both brand-name and compounded medication options. That said, Sesame Care may be the better fit if you are looking for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
Enhance MD scores 8.3/10 in our evaluation at $212/month, while Sesame Care scores 7.2/10 at $208/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | Sesame Care |
|---|---|---|
| Monthly Price | $212 | $208 |
| Rating | 8.3 / 10 | 7.2 / 10 |
| Medication Type | Brand & Compounded | Brand-Name Only |
| Insurance Accepted | No | Yes |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | $59/mo care subscription (12-month commitment) |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified physicians | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Semaglutide $212/mo on the 12-month plan, same price at every dose, labs every 6 months included
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent pricing: a $59/mo care subscription plus the manufacturer's own medication price
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
People who specifically want brand-name FDA-approved GLP-1s and will commit to a year of care — not the cheapest route, and no compounded option
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Sesame Care at $208/month. Sesame has moved to a "Success by Sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — Wegovy from $149/mo brings the all-in to roughly $208/mo, and Zepbound from $299/mo to roughly $358/mo. Brand-name FDA-approved medication only; Sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. Sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. Verified August 31, 2026..
Enhance MD has the edge with a 8.3 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Choose Sesame Care which exclusively prescribes brand-name medications.
Compare their support: Enhance MD offers board-certified physicians, while Sesame Care provides licensed physicians, per-visit model.
Enhance MD at $212/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Sesame Care?
Enhance MD has a 8.3 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while Sesame Care is best for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
How much does Enhance MD cost compared to Sesame Care?
Enhance MD starts at $212/month (semaglutide $212/mo and tirzepatide $280/mo on the 12-month plan (billed every 48 weeks); 6-month $224 / $296, 3-month $237 / $313, 1-month $249 / $329. same price at every dose, 'no hidden fees', provider care and labs every 6 months included. a labor day promotion advertises up to $150 off your first order only ($100 off multi-month, $50 off 1-month); the ongoing rates above are what you actually pay. a microdosing tirzepatide plan at $169/mo is capped at 1mg/week and is not a full-dose price. verified september 6, 2026.), while Sesame Care starts at $208/month (sesame has moved to a "success by sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — wegovy from $149/mo brings the all-in to roughly $208/mo, and zepbound from $299/mo to roughly $358/mo. brand-name fda-approved medication only; sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. verified august 31, 2026.).
Do Enhance MD and Sesame Care accept insurance?
Enhance MD does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does Enhance MD offer vs Sesame Care?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Sesame Care offers Wegovy, Wegovy HD, Wegovy (oral), Zepbound, Zepbound KwikPen, Foundayo.
Can I cancel Enhance MD or Sesame Care at any time?
Enhance MD allows cancel anytime. Sesame Care also allows cancel anytime.
Are Enhance MD and Sesame Care available in my state?
Enhance MD is available in all 50 states. Sesame Care is available in all 50 states.
Not sure Enhance MD or Sesame Care is right for you?
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