Enhance MD vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Enhance MD and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Enhance MD
Between these two providers, Enhance MD is our pick for most users. It offers a higher overall rating (8.3 vs 7.2). That said, Sesame Care may be the better fit if you are looking for users with insurance who want cheap doctor visits — medication costs are separate and not included.
Enhance MD scores 8.3/10 in our independent evaluation at $249/month, while Sesame Care scores 7.2/10 at $225/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Enhance MD | Sesame Care |
|---|---|---|
| Monthly Price | $249 | $225 |
| Rating | 8.3 / 10 | 7.2 / 10 |
| Medication Type | Brand & Compounded | Brand & Compounded |
| Insurance Accepted | No | Yes |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | $25-75 |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Board-certified physicians | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent per-visit pricing with no subscriptions
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
Users with insurance who want cheap doctor visits — medication costs are separate and not included
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Sesame Care at $225/month. $25-75 per visit + medication at pharmacy prices ($200-1,400/mo). Total starting cost ~$225/mo with insurance savings cards. Medication NOT included in visit fee..
Enhance MD has the edge with a 8.3 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Compare their support: Enhance MD offers board-certified physicians, while Sesame Care provides licensed physicians, per-visit model.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is Enhance MD better than Sesame Care?
Enhance MD has a 8.3 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — Enhance MD is best for budget-conscious users interested in combination therapies, while Sesame Care is best for users with insurance who want cheap doctor visits — medication costs are separate and not included.
How much does Enhance MD cost compared to Sesame Care?
Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%), while Sesame Care starts at $225/month ($25-75 per visit + medication at pharmacy prices ($200-1,400/mo). total starting cost ~$225/mo with insurance savings cards. medication not included in visit fee.).
Do Enhance MD and Sesame Care accept insurance?
Enhance MD does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does Enhance MD offer vs Sesame Care?
Enhance MD offers Semaglutide, Tirzepatide, NAD+. Sesame Care offers Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus.
Can I cancel Enhance MD or Sesame Care at any time?
Enhance MD allows cancel anytime. Sesame Care also allows cancel anytime.
Are Enhance MD and Sesame Care available in my state?
Enhance MD is available in all 50 states. Sesame Care is available in all 50 states.