Direct Meds GLP-1 vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Direct Meds GLP-1 and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Direct Meds GLP-1
Between these two providers, Direct Meds GLP-1 is our pick for most users. It offers a higher overall rating (8.5 vs 7.2). That said, Sesame Care may be the better fit if you are looking for users with insurance who want cheap doctor visits — medication costs are separate and not included.
Direct Meds GLP-1 scores 8.5/10 in our independent evaluation at $280/month, while Sesame Care scores 7.2/10 at $225/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Direct Meds GLP-1 | Sesame Care |
|---|---|---|
| Monthly Price | $280 | $225 |
| Rating | 8.5 / 10 | 7.2 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | Yes |
| States Available | 45 states | All 50 states |
| Consultation Fee | Included | $25-75 |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed providers | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Direct Meds GLP-1: Detailed Look
Direct Meds GLP-1
Direct-to-consumer GLP-1 access with competitive pricing
Pros
- All-inclusive pricing — medication included in monthly cost
- Straightforward, simple enrollment process
- No surprise fees or hidden charges
Cons
- Compounded medications only — not FDA-approved brand drugs
- Less established brand with fewer online reviews
Users wanting simple, all-inclusive pricing without insurance
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent per-visit pricing with no subscriptions
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
Users with insurance who want cheap doctor visits — medication costs are separate and not included
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Sesame Care at $225/month. $25-75 per visit + medication at pharmacy prices ($200-1,400/mo). Total starting cost ~$225/mo with insurance savings cards. Medication NOT included in visit fee..
Direct Meds GLP-1 has the edge with a 8.5 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Direct Meds GLP-1 focuses on compounded medications at a lower price point.
Compare their support: Direct Meds GLP-1 offers licensed providers, while Sesame Care provides licensed physicians, per-visit model.
Direct Meds GLP-1 at $280/month may offer features that justify the premium.
Frequently Asked Questions
Is Direct Meds GLP-1 better than Sesame Care?
Direct Meds GLP-1 has a 8.5 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — Direct Meds GLP-1 is best for users wanting simple, all-inclusive pricing without insurance, while Sesame Care is best for users with insurance who want cheap doctor visits — medication costs are separate and not included.
How much does Direct Meds GLP-1 cost compared to Sesame Care?
Direct Meds GLP-1 starts at $280/month (flat monthly rate, medication included), while Sesame Care starts at $225/month ($25-75 per visit + medication at pharmacy prices ($200-1,400/mo). total starting cost ~$225/mo with insurance savings cards. medication not included in visit fee.).
Do Direct Meds GLP-1 and Sesame Care accept insurance?
Direct Meds GLP-1 does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does Direct Meds GLP-1 offer vs Sesame Care?
Direct Meds GLP-1 offers Compounded Semaglutide, Compounded Tirzepatide. Sesame Care offers Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus.
Can I cancel Direct Meds GLP-1 or Sesame Care at any time?
Direct Meds GLP-1 allows cancel anytime. Sesame Care also allows cancel anytime.
Are Direct Meds GLP-1 and Sesame Care available in my state?
Direct Meds GLP-1 is available in 45 states. Sesame Care is available in all 50 states.