Direct Meds GLP-1 vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Direct Meds GLP-1 and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Direct Meds GLP-1
Between these two providers, Direct Meds GLP-1 is our pick for most users. It offers a higher overall rating (8.5 vs 7.8). That said, Sesame Care may be the better fit if you are looking for users who want cheap doctor visits and already have insurance to cover brand-name medications.
Side-by-Side Comparison
| Feature | Direct Meds GLP-1 | Sesame Care |
|---|---|---|
| Monthly Price | $280 | $25 |
| Rating | 8.5 / 10 | 7.8 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | Yes |
| States Available | 45 states | All 50 states |
| Consultation Fee | Included | $25-75 |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed providers | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated March 2026.
Direct Meds GLP-1: Detailed Look
Direct Meds GLP-1
Direct-to-consumer GLP-1 access with competitive pricing
Pros
- All-inclusive pricing — medication included in monthly cost
- Straightforward, simple enrollment process
- No surprise fees or hidden charges
Cons
- Compounded medications only — not FDA-approved brand drugs
- Less established brand with fewer online reviews
Users wanting simple, all-inclusive pricing without insurance
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent per-visit pricing with no subscriptions
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
Users who want cheap doctor visits and already have insurance to cover brand-name medications
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Sesame Care at $25/month. $25-75 per visit; medication costs separate.
Direct Meds GLP-1 has the edge with a 8.5 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Direct Meds GLP-1 focuses on compounded medications at a lower price point.
Compare their support: Direct Meds GLP-1 offers licensed providers, while Sesame Care provides licensed physicians, per-visit model.
Direct Meds GLP-1 at $280/month may offer features that justify the premium.
Frequently Asked Questions
Is Direct Meds GLP-1 better than Sesame Care?
Direct Meds GLP-1 has a 8.5 rating while Sesame Care has a 7.8 rating. The better choice depends on your priorities — Direct Meds GLP-1 is best for users wanting simple, all-inclusive pricing without insurance, while Sesame Care is best for users who want cheap doctor visits and already have insurance to cover brand-name medications.
How much does Direct Meds GLP-1 cost compared to Sesame Care?
Direct Meds GLP-1 starts at $280/month (flat monthly rate, medication included), while Sesame Care starts at $25/month ($25-75 per visit; medication costs separate).
Do Direct Meds GLP-1 and Sesame Care accept insurance?
Direct Meds GLP-1 does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does Direct Meds GLP-1 offer vs Sesame Care?
Direct Meds GLP-1 offers Compounded Semaglutide, Compounded Tirzepatide. Sesame Care offers Ozempic, Wegovy, Mounjaro, Zepbound, Rybelsus.
Can I cancel Direct Meds GLP-1 or Sesame Care at any time?
Direct Meds GLP-1 allows cancel anytime. Sesame Care also allows cancel anytime.
Are Direct Meds GLP-1 and Sesame Care available in my state?
Direct Meds GLP-1 is available in 45 states. Sesame Care is available in all 50 states.