Direct Meds GLP-1 vs HealthRX
Recorded prices, access and terms.
The short answer
- Cheapest to start, semaglutide: HealthRX is lower for semaglutide on the monthly plan: $125/mo against $249/mo at Direct Meds GLP-1, a $124 gap.
- Cheapest to start, tirzepatide: HealthRX is lower for tirzepatide on the monthly plan: $201/mo against $297/mo at Direct Meds GLP-1, a $96 gap.
- Cheapest over 12 months, semaglutide: Over 12 months HealthRX is lower for semaglutide: $1,164 on the 12-month plan, against $2,988 at Direct Meds GLP-1 on 12 months on the monthly plan.
- Cheapest over 12 months, tirzepatide: Over 12 months HealthRX is lower for tirzepatide: $2,124 on the 12-month plan, against $3,564 at Direct Meds GLP-1 on 12 months on the monthly plan.
- Broadest availability: HealthRX is recorded in 50 states, Direct Meds GLP-1 in 45.
- Drugs: Direct Meds GLP-1 lists compounded medication only; HealthRX lists compounded medication only.
Price lines compare recorded monthly-plan subtotals and term totals, as on our price pages. A lower recorded rate is not a complete cost: labs, dose changes and the amount due today can differ.
Decision table
The entries below are recorded provider statements unless a regulatory source is linked. A provider webpage does not independently verify its licenses or quality. Direct Meds GLP-1 source · HealthRX source.
| Compare | Direct Meds GLP-1 | HealthRX |
|---|---|---|
| Recorded monthly-plan price | $249/mo semaglutide, $297/mo tirzepatide | $125/mo semaglutide, $201/mo tirzepatide |
| Recorded medication/program subtotal | Recorded medication and program subtotal: semaglutide: $249/month; tirzepatide: $297/month. Other required fees, labs, dose changes and renewal terms are not established. This is not a verified all-in treatment cost. | Recorded medication and program subtotal: semaglutide: $125/month; tirzepatide: $201/month. Other required fees, labs, dose changes and renewal terms are not established. This is not a verified all-in treatment cost. |
| Lowest 12-month total on the record | semaglutide $2,988 (12 months on the monthly plan); tirzepatide $3,564 (12 months on the monthly plan) | semaglutide $1,164 (the 12-month plan); tirzepatide $2,124 (the 12-month plan) |
| Full required monthly cost | Not established: consultation, labs, membership, dose changes and shipping must be checked | Not established: consultation, labs, membership, dose changes and shipping must be checked |
| Drug type listed | Compounded | Compounded |
| Oral option | Listed | Injections only on the record |
| Consultation | Included in the record; current conditions unconfirmed | Included, per its pricing page in the record; current conditions unconfirmed |
| Membership or program fee | Not separately recorded; do not assume zero. | Not separately recorded; do not assume zero. |
| Shipping | Recorded as included; confirm for your address | Recorded as included; confirm for your address |
| Labs | Required tests and any lab charge are not recorded. | Required tests and any lab charge are not recorded. |
| Insurance | Self-pay on the record | Self-pay on the record |
| Pharmacy license | Not independently verified. Obtain the dispensing pharmacy name and verify its state license. | Not independently verified. Obtain the dispensing pharmacy name and verify its state license. |
| Reported states | 45; confirm eligibility and clinician licensing in your state | 50; confirm eligibility and clinician licensing in your state |
| Cancellation | Cancellation reported; notice, minimum term and refund conditions unconfirmed | Cancellation reported; notice, minimum term and refund conditions unconfirmed |
| Clinician/support as reported | Licensed providers | Independent clinicians licensed in your state, with provider messaging and refill coordination, per its site |
| Trustpilot | 4.5/5 from 17,622 reviews (read Nov 5, 2026) | No Trustpilot profile we could quote |
| Recorded provider check | 2026-09-13 | 2026-11-09 |
Price by plan and term
Each rate is a per-month amount for the plan named, from the seller's own page on the date shown. A term plan's rate needs the full term; the total under it is the rate times the months.
Direct Meds GLP-1
| Plan or term | Semaglutide | Tirzepatide | Source and read date |
|---|---|---|---|
| Monthly plan | $249/mo | $297/mo | Direct Meds GLP-1 page, read Sep 13, 2026 |
Terms (April 16, 2026): a prescription order can be cancelled only within 24 hours of placing it, subscriptions bill every 30 days and can be cancelled up to 48 hours before the next processing date in the portal, and medication already received is not refundable.
HealthRX
| Plan or term | Semaglutide | Tirzepatide | Source and read date |
|---|---|---|---|
| Monthly plan | $125/mo | $201/mo | HealthRX page, read Nov 9, 2026 |
| 12-month plan | $97/mo$1,164 over 12 months | $177/mo$2,124 over 12 months | HealthRX page, read Nov 9, 2026 |
Read November 9, 2026 on healthrx.com/pricing and the product pages: $39 for the first month, then compounded semaglutide $125 a month or compounded tirzepatide $201 a month, renewing until canceled. The 12-month plan is shown as $97 (semaglutide) or $177 (tirzepatide) a month, with $39 due today. Its earlier plan-by-plan upfront totals (read November 6) were not shown on these pages and are not re-read, so we do not carry them. The plan price includes the provider review, medication and overnight shipping per the seller; lab charges are not stated, so they are unknown.
What is included
Direct Meds GLP-1
Visits: consultation recorded as "Included". Care: Licensed providers.
Shipping: recorded as included.
Labs: Required tests and any lab charge are not recorded.
Dose increases: A price for each dose step is not recorded.
What Direct Meds GLP-1 lists:
- Straightforward, simple enrollment process
HealthRX
Visits: consultation recorded as "Included, per its pricing page". Care: Independent clinicians licensed in your state, with provider messaging and refill coordination, per its site.
Shipping: recorded as included.
Labs: Required tests and any lab charge are not recorded.
Dose increases: A price for each dose step is not recorded.
What HealthRX lists:
- Says the plan price includes the provider review, the prescription when appropriate, the medication and overnight shipping, with no separate visit or membership fee
- Says it gives a full refund if a provider does not approve you
- Its pricing page says plans are HSA and FSA eligible
States served
Direct Meds GLP-1: 45 states
Recorded as available in 45 states.
The record names no excluded state. Confirm yours at intake.
HealthRX: 50 states
Recorded as available in all 50 states.
The record names no excluded state. Confirm yours at intake.
State-by-state costs and Medicaid notes are on the GLP-1 cost by state pages.
Drugs offered
Direct Meds GLP-1: compounded medication only
- Compounded Semaglutide (Sublingual)
- Compounded Semaglutide (Injectable)
- Compounded Tirzepatide
An oral form is listed.
HealthRX: compounded medication only
- Compounded Semaglutide
- Compounded Tirzepatide
Injections only on the record.
Compounded drugs are made by a pharmacy for a patient and are not the brand products. Compounded vs brand-name GLP-1.
Membership and other fees
- Direct Meds GLP-1: Not separately recorded; do not assume zero.
- HealthRX: Not separately recorded; do not assume zero.
A fee missing from the record is unknown, not zero.
Cancellation and refunds
Direct Meds GLP-1
Recorded: prescription orders cancellable within 24 hours; subscription cancellation at least 48 hours before processing. Received medication is non-refundable.
HealthRX
Recorded: cancel by emailing support, and it refunds any unshipped dose; full refund if a provider does not approve; dispensed medication cannot be returned.
- The monthly plan bills every month until canceled, with a $39 first month on either medication.
- Its pricing page says the plan price includes the provider review, medication and overnight shipping, with no separate visit or membership fee. Lab charges are not stated on the pages we read, so they are unknown. It says it refunds any unshipped dose on cancellation; dispensed medication cannot be returned.
Which should you choose?
Direct Meds GLP-1
On the record, Direct Meds GLP-1 suits a reader who wants an oral option.
HealthRX
On the record, HealthRX suits a reader who wants the lower semaglutide monthly-plan rate, the lower tirzepatide monthly-plan rate, the lower 12-month semaglutide total, the lower 12-month tirzepatide total and more states on the record (50 against 45).
Ask each provider for the full cost at your prescribed dose, required labs and visits, the dispensing pharmacy, the clinician's state license, renewal charges and written refund terms. Compare those answers with your clinician.
Compounded drugs are not FDA-approved and do not undergo FDA review for safety, effectiveness or quality before marketing. FDA source and recommendations.
Direct Meds GLP-1: evidence and terms
Recorded FDA letter (2025-09-09): FDA found claims on directmeds.com that its compounded semaglutide and tirzepatide contain 'the same active ingredient' as the brand drugs false or misleading, making the products misbranded under FD&C Act sections 502(a) and 502(bb). FDA letter.
Read Direct Meds GLP-1's sourced record · Direct Meds GLP-1 source
HealthRX: evidence and terms
Price-only check 2026-11-09: Monthly plan: $125 semaglutide, $201 tirzepatide, after a $39 first month (pricing page and product page, read 2026-11-09). Price source.
Direct Meds GLP-1 vs HealthRX: questions
Which is cheaper, Direct Meds GLP-1 or HealthRX?
HealthRX is lower for semaglutide on the monthly plan: $125/mo against $249/mo at Direct Meds GLP-1, a $124 gap. HealthRX is lower for tirzepatide on the monthly plan: $201/mo against $297/mo at Direct Meds GLP-1, a $96 gap. These are medication and recorded program-fee subtotals; labs, dose changes and other charges may be extra.
Which costs less over a year, Direct Meds GLP-1 or HealthRX?
Over 12 months HealthRX is lower for semaglutide: $1,164 on the 12-month plan, against $2,988 at Direct Meds GLP-1 on 12 months on the monthly plan. Over 12 months HealthRX is lower for tirzepatide: $2,124 on the 12-month plan, against $3,564 at Direct Meds GLP-1 on 12 months on the monthly plan. A term plan commits you for the full term, so check its refund rules first.
Is Direct Meds GLP-1 or HealthRX available in more states?
HealthRX is recorded in more states: 50 against 45. Confirm your state at intake.
Do Direct Meds GLP-1 and HealthRX offer brand-name or compounded GLP-1?
Direct Meds GLP-1 lists compounded medication only (Compounded Semaglutide (Sublingual), Compounded Semaglutide (Injectable), Compounded Tirzepatide). HealthRX lists compounded medication only (Compounded Semaglutide, Compounded Tirzepatide). Compounded drugs are not FDA-approved.
Does Direct Meds GLP-1 or HealthRX charge a membership fee?
Direct Meds GLP-1: Not separately recorded; do not assume zero. HealthRX: Not separately recorded; do not assume zero.
Can you cancel Direct Meds GLP-1 or HealthRX at any time?
Direct Meds GLP-1: Recorded: prescription orders cancellable within 24 hours; subscription cancellation at least 48 hours before processing. Received medication is non-refundable. HealthRX: Recorded: cancel by emailing support, and it refunds any unshipped dose; full refund if a provider does not approve; dispensed medication cannot be returned.
Are the visit and shipping included with Direct Meds GLP-1 and HealthRX?
Direct Meds GLP-1: consultation recorded as "Included", shipping recorded as included. HealthRX: consultation recorded as "Included, per its pricing page", shipping recorded as included.
Do Direct Meds GLP-1 or HealthRX take insurance?
Neither is recorded as accepting insurance; both are self-pay on our record.
Does Direct Meds GLP-1 or HealthRX offer a pill or tablet?
Direct Meds GLP-1 lists an oral option; HealthRX lists injections only on our record.
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