Direct Meds GLP-1 vs Enhance MD
Recorded prices, access and terms.
The short answer
- Cheapest to start, semaglutide: Both record $249 for semaglutide on the monthly plan.
- Cheapest to start, tirzepatide: Direct Meds GLP-1 is lower for tirzepatide on the monthly plan: $297/mo against $329/mo at Enhance MD, a $32 gap.
- Cheapest over 12 months, semaglutide: Over 12 months both come to $2,988 for semaglutide in medication and recorded fees.
- Cheapest over 12 months, tirzepatide: Over 12 months Direct Meds GLP-1 is lower for tirzepatide: $3,564 on 12 months on the monthly plan, against $3,948 at Enhance MD on 12 months on the monthly plan.
- Broadest availability: Enhance MD is recorded in 50 states, Direct Meds GLP-1 in 45.
- Drugs: Direct Meds GLP-1 lists compounded medication only; Enhance MD lists brand-name and compounded medication.
Price lines compare recorded monthly-plan subtotals and term totals, as on our price pages. A lower recorded rate is not a complete cost: labs, dose changes and the amount due today can differ.
Decision table
The entries below are recorded provider statements unless a regulatory source is linked. A provider webpage does not independently verify its licenses or quality. Direct Meds GLP-1 source · Enhance MD source.
| Compare | Direct Meds GLP-1 | Enhance MD |
|---|---|---|
| Recorded monthly-plan price | $249/mo semaglutide, $297/mo tirzepatide | $249/mo semaglutide, $329/mo tirzepatide |
| Recorded medication/program subtotal | Recorded medication and program subtotal: semaglutide: $249/month; tirzepatide: $297/month. Other required fees, labs, dose changes and renewal terms are not established. This is not a verified all-in treatment cost. | Recorded medication and program subtotal: semaglutide: $249/month; tirzepatide: $329/month. Other required fees, labs, dose changes and renewal terms are not established. This is not a verified all-in treatment cost. |
| Lowest 12-month total on the record | semaglutide $2,988 (12 months on the monthly plan); tirzepatide $3,564 (12 months on the monthly plan) | semaglutide $2,988 (12 months on the monthly plan); tirzepatide $3,948 (12 months on the monthly plan) |
| Full required monthly cost | Not established: consultation, labs, membership, dose changes and shipping must be checked | Not established: consultation, labs, membership, dose changes and shipping must be checked |
| Drug type listed | Compounded | Brand-name and compounded |
| Oral option | Listed | Injections only on the record |
| Consultation | Included in the record; current conditions unconfirmed | Included in the record; current conditions unconfirmed |
| Membership or program fee | Not separately recorded; do not assume zero. | Not separately recorded; do not assume zero. |
| Shipping | Recorded as included; confirm for your address | Recorded as included; confirm for your address |
| Labs | Required tests and any lab charge are not recorded. | Provider says included every 6 months; additional testing unknown. |
| Insurance | Self-pay on the record | Self-pay on the record |
| Pharmacy license | Not independently verified. Obtain the dispensing pharmacy name and verify its state license. | Not independently verified. Obtain the dispensing pharmacy name and verify its state license. |
| Reported states | 45; confirm eligibility and clinician licensing in your state | 50; confirm eligibility and clinician licensing in your state |
| Cancellation | Cancellation reported; notice, minimum term and refund conditions unconfirmed | Cancellation reported; notice, minimum term and refund conditions unconfirmed |
| Clinician/support as reported | Licensed providers | Board-certified physicians |
| Trustpilot | 4.5/5 from 17,622 reviews (read Nov 5, 2026) | 4/5 from 162 reviews (read Nov 5, 2026) |
| Recorded provider check | 2026-09-13 | 2026-11-06 |
Price by plan and term
Each rate is a per-month amount for the plan named, from the seller's own page on the date shown. A term plan's rate needs the full term; the total under it is the rate times the months.
Direct Meds GLP-1
| Plan or term | Semaglutide | Tirzepatide | Source and read date |
|---|---|---|---|
| Monthly plan | $249/mo | $297/mo | Direct Meds GLP-1 page, read Sep 13, 2026 |
Terms (April 16, 2026): a prescription order can be cancelled only within 24 hours of placing it, subscriptions bill every 30 days and can be cancelled up to 48 hours before the next processing date in the portal, and medication already received is not refundable.
Enhance MD
| Plan or term | Semaglutide | Tirzepatide | Source and read date |
|---|---|---|---|
| Monthly plan | $249/mo | $329/mo | Enhance MD page, read Nov 6, 2026 |
Semaglutide $212/mo and tirzepatide $280/mo on the 12-month plan (billed every 48 weeks); 6-month $224 / $296, 3-month $237 / $313, 1-month $249 / $329. Same price at every dose, 'no hidden fees', provider care and labs every 6 months included. A Labor Day promotion advertises up to $150 off your FIRST order only ($100 off multi-month, $50 off 1-month); the ongoing rates above are what you actually pay. Read September 6, 2026.
What is included
Direct Meds GLP-1
Visits: consultation recorded as "Included". Care: Licensed providers.
Shipping: recorded as included.
Labs: Required tests and any lab charge are not recorded.
Dose increases: A price for each dose step is not recorded.
What Direct Meds GLP-1 lists:
- Straightforward, simple enrollment process
Enhance MD
Visits: consultation recorded as "Included". Care: Board-certified physicians.
Shipping: recorded as included.
Labs: Provider says included every 6 months; additional testing unknown.
Dose increases: The seller says its price stays the same as the dose rises; the full dose schedule is not independently checked.
What Enhance MD lists:
- Unique NAD+ therapy option alongside GLP-1
States served
Direct Meds GLP-1: 45 states
Recorded as available in 45 states.
The record names no excluded state. Confirm yours at intake.
Enhance MD: 50 states
Recorded as available in all 50 states.
The record names no excluded state. Confirm yours at intake.
State-by-state costs and Medicaid notes are on the GLP-1 cost by state pages.
Drugs offered
Direct Meds GLP-1: compounded medication only
- Compounded Semaglutide (Sublingual)
- Compounded Semaglutide (Injectable)
- Compounded Tirzepatide
An oral form is listed.
Enhance MD: brand-name and compounded medication
- Semaglutide
- Tirzepatide
- NAD+
Injections only on the record.
Compounded drugs are made by a pharmacy for a patient and are not the brand products. Compounded vs brand-name GLP-1.
Membership and other fees
- Direct Meds GLP-1: Not separately recorded; do not assume zero.
- Enhance MD: Not separately recorded; do not assume zero.
A fee missing from the record is unknown, not zero.
Cancellation and refunds
Direct Meds GLP-1
Recorded: prescription orders cancellable within 24 hours; subscription cancellation at least 48 hours before processing. Received medication is non-refundable.
Enhance MD
Recorded as cancel anytime; notice deadlines, prepaid-plan limits and refund rights are not fully recorded.
- It says it refunds you if your provider finds you ineligible during onboarding.
Which should you choose?
Direct Meds GLP-1
On the record, Direct Meds GLP-1 suits a reader who wants the lower tirzepatide monthly-plan rate, the lower 12-month tirzepatide total and an oral option.
Enhance MD
On the record, Enhance MD suits a reader who wants more states on the record (50 against 45) and brand-name, FDA-approved medication.
Ask each provider for the full cost at your prescribed dose, required labs and visits, the dispensing pharmacy, the clinician's state license, renewal charges and written refund terms. Compare those answers with your clinician.
Compounded drugs are not FDA-approved and do not undergo FDA review for safety, effectiveness or quality before marketing. FDA source and recommendations.
Direct Meds GLP-1: evidence and terms
Recorded FDA letter (2025-09-09): FDA found claims on directmeds.com that its compounded semaglutide and tirzepatide contain 'the same active ingredient' as the brand drugs false or misleading, making the products misbranded under FD&C Act sections 502(a) and 502(bb). FDA letter.
Read Direct Meds GLP-1's sourced record · Direct Meds GLP-1 source
Enhance MD: evidence and terms
Price-only check 2026-11-06: Homepage shows $212 and $280 standing rates after first-month promotions; one-month $249 and $329 are from the earlier read. Price source.
Direct Meds GLP-1 vs Enhance MD: questions
Which is cheaper, Direct Meds GLP-1 or Enhance MD?
Both record $249 for semaglutide on the monthly plan. Direct Meds GLP-1 is lower for tirzepatide on the monthly plan: $297/mo against $329/mo at Enhance MD, a $32 gap. These are medication and recorded program-fee subtotals; labs, dose changes and other charges may be extra.
Which costs less over a year, Direct Meds GLP-1 or Enhance MD?
Over 12 months both come to $2,988 for semaglutide in medication and recorded fees. Over 12 months Direct Meds GLP-1 is lower for tirzepatide: $3,564 on 12 months on the monthly plan, against $3,948 at Enhance MD on 12 months on the monthly plan. A term plan commits you for the full term, so check its refund rules first.
Is Direct Meds GLP-1 or Enhance MD available in more states?
Enhance MD is recorded in more states: 50 against 45. Confirm your state at intake.
Do Direct Meds GLP-1 and Enhance MD offer brand-name or compounded GLP-1?
Direct Meds GLP-1 lists compounded medication only (Compounded Semaglutide (Sublingual), Compounded Semaglutide (Injectable), Compounded Tirzepatide). Enhance MD lists brand-name and compounded medication (Semaglutide, Tirzepatide, NAD+). Compounded drugs are not FDA-approved.
Does Direct Meds GLP-1 or Enhance MD charge a membership fee?
Direct Meds GLP-1: Not separately recorded; do not assume zero. Enhance MD: Not separately recorded; do not assume zero.
Can you cancel Direct Meds GLP-1 or Enhance MD at any time?
Direct Meds GLP-1: Recorded: prescription orders cancellable within 24 hours; subscription cancellation at least 48 hours before processing. Received medication is non-refundable. Enhance MD: Recorded as cancel anytime; notice deadlines, prepaid-plan limits and refund rights are not fully recorded.
Are the visit and shipping included with Direct Meds GLP-1 and Enhance MD?
Direct Meds GLP-1: consultation recorded as "Included", shipping recorded as included. Enhance MD: consultation recorded as "Included", shipping recorded as included.
Do Direct Meds GLP-1 or Enhance MD take insurance?
Neither is recorded as accepting insurance; both are self-pay on our record.
Does Direct Meds GLP-1 or Enhance MD offer a pill or tablet?
Direct Meds GLP-1 lists an oral option; Enhance MD lists injections only on our record.
Compare the full provider directory · Compare recorded price subtotals