Trimi vs Sesame Care: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Trimi and Sesame Care to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Trimi
Between these two providers, Trimi is our pick for most users. It offers a higher overall rating (9.2 vs 7.2), more affordable pricing. That said, Sesame Care may be the better fit if you are looking for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
Trimi scores 9.2/10 in our independent evaluation at $99/month, while Sesame Care scores 7.2/10 at $208/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Trimi | Sesame Care |
|---|---|---|
| Monthly Price | $99 | $208 |
| Rating | 9.2 / 10 | 7.2 / 10 |
| Medication Type | Compounded Only | Brand-Name Only |
| Insurance Accepted | No | Yes |
| States Available | 47 states | All 50 states |
| Consultation Fee | Included | $59/mo care subscription (12-month commitment) |
| Shipping | Free Shipping | Paid |
| Cancel Anytime | Yes | Yes |
| Medical Support | US-licensed clinicians, telehealth consults, dose adjustments | Licensed physicians, per-visit model |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Trimi: Detailed Look
Trimi
Compounded GLP-1 from $99 with US-licensed clinicians
Pros
- Tirzepatide at $125/month — lowest tirzepatide price among verified programs
- Semaglutide at $99/month matches the market floor
- US-licensed clinicians with dose-adjustment support
- Free shipping to your door
Cons
- New program with a short independent track record
- No brand-name (Wegovy/Zepbound) pathway
Cash-pay users who want the cheapest tirzepatide from a US-licensed program
Sesame Care: Detailed Look
Sesame Care
Affordable telehealth marketplace connecting patients with doctors from $25
Pros
- Lowest consultation cost — visits from just $25
- Prescribes brand-name FDA-approved medications
- Transparent pricing: a $59/mo care subscription plus the manufacturer's own medication price
- Wide network of licensed physicians across all 50 states
Cons
- Medication cost is separate and not included in visit fee
- No compounded options — brand-name only (higher drug cost)
People who specifically want brand-name FDA-approved GLP-1s and will commit to a year of care — not the cheapest route, and no compounded option
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Trimi at $99/month. Semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. Same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. Verified September 6, 2026..
Trimi has the edge with a 9.2 rating.
Sesame Care accepts insurance, which can significantly reduce your out-of-pocket cost.
Choose Sesame Care which exclusively prescribes brand-name medications.
Trimi focuses on compounded medications at a lower price point.
Compare their support: Trimi offers us-licensed clinicians, telehealth consults, dose adjustments, while Sesame Care provides licensed physicians, per-visit model.
Sesame Care at $208/month may offer features that justify the premium.
Frequently Asked Questions
Is Trimi better than Sesame Care?
Trimi has a 9.2 rating while Sesame Care has a 7.2 rating. The better choice depends on your priorities — Trimi is best for cash-pay users who want the cheapest tirzepatide from a us-licensed program, while Sesame Care is best for people who specifically want brand-name fda-approved glp-1s and will commit to a year of care — not the cheapest route, and no compounded option.
How much does Trimi cost compared to Sesame Care?
Trimi starts at $99/month (semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. verified september 6, 2026.), while Sesame Care starts at $208/month (sesame has moved to a "success by sesame" subscription: $59/mo for care (priced on a 12-month commitment) plus medication billed separately — wegovy from $149/mo brings the all-in to roughly $208/mo, and zepbound from $299/mo to roughly $358/mo. brand-name fda-approved medication only; sesame no longer offers a compounded option, so it does not appear in our compounded price ladders. sesame notes medication pricing may vary by treatment, dose, pharmacy and provider, so these are floors rather than guarantees. verified august 31, 2026.).
Do Trimi and Sesame Care accept insurance?
Trimi does not accept insurance. Sesame Care accepts insurance.
Which GLP-1 medications does Trimi offer vs Sesame Care?
Trimi offers Compounded Semaglutide, Compounded Tirzepatide. Sesame Care offers Wegovy, Wegovy HD, Wegovy (oral), Zepbound, Zepbound KwikPen, Foundayo.
Can I cancel Trimi or Sesame Care at any time?
Trimi allows cancel anytime. Sesame Care also allows cancel anytime.
Are Trimi and Sesame Care available in my state?
Trimi is available in 47 states. Sesame Care is available in all 50 states.
Not sure Trimi or Sesame Care is right for you?
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