Trimi vs PlexusDx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Trimi and PlexusDx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Trimi
Between these two providers, Trimi is our pick for most users. It offers a higher overall rating (9.2 vs 7.6), more affordable pricing. That said, PlexusDx may be the better fit if you are looking for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
Trimi scores 9.2/10 in our evaluation at $99/month, while PlexusDx scores 7.6/10 at $149/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). We earn affiliate commissions from some providers, disclosed on this page; no provider can pay to fake safety, licensing, or hide the downsides. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Trimi | PlexusDx |
|---|---|---|
| Monthly Price | $99 | $149 |
| Rating | 9.2 / 10 | 7.6 / 10 |
| Medication Type | Compounded Only | Compounded Only |
| Insurance Accepted | No | No |
| States Available | 47 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | US-licensed clinicians, telehealth consults, dose adjustments | US-licensed clinicians (LionMD network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Trimi: Detailed Look
Trimi
Compounded GLP-1 from $99 with US-licensed clinicians
Pros
- Tirzepatide at $125/month — lowest tirzepatide price among verified programs
- Semaglutide at $99/month matches the market floor
- US-licensed clinicians with dose-adjustment support
- Free shipping to your door
Cons
- New program with a short independent track record
- No brand-name (Wegovy/Zepbound) pathway
Cash-pay users who want the cheapest tirzepatide from a US-licensed program
PlexusDx: Detailed Look
PlexusDx
All-inclusive compounded GLP-1 with flat pricing at every dose and an optional genetic test
Pros
- All-inclusive pricing with no membership fee: consult, prescription, medication, supplies and shipping in one monthly charge
- Flat price at every dose level, so the monthly cost does not rise as your dose is titrated up
- LegitScript certified (September 18, 2026), with its 503A compounding pharmacies named on the site
- Available in all 50 states, with injection, oral and low-dose microdose options
Cons
- Compounded medications are not FDA-approved
- Month-to-month pricing ($189 semaglutide, $289 tirzepatide) is well above the cheapest programs; the lower rates need a 3- or 6-month commitment
- No published refund policy, and the genetic test is an extra $99 that does not decide which medication you get
Users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Trimi at $99/month. Semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. Same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. Verified September 6, 2026..
Trimi has the edge with a 9.2 rating.
Compare their support: Trimi offers us-licensed clinicians, telehealth consults, dose adjustments, while PlexusDx provides us-licensed clinicians (lionmd network) via async intake, monthly check-ins and provider-reviewed refills; five states require a scheduled video consultation.
PlexusDx at $149/month may offer features that justify the premium.
Frequently Asked Questions
Is Trimi better than PlexusDx?
Trimi has a 9.2 rating while PlexusDx has a 7.6 rating. The better choice depends on your priorities — Trimi is best for cash-pay users who want the cheapest tirzepatide from a us-licensed program, while PlexusDx is best for users who want one all-inclusive price that never changes with dose, and are curious about an optional genetic report.
How much does Trimi cost compared to PlexusDx?
Trimi starts at $99/month (semaglutide $99/mo and tirzepatide $125/mo on the annual plan ($1,188 / $1,500 billed once yearly); 6-month $120 / $175, quarterly $145 / $199, month-to-month with no commitment $175 / $235. same price at every dose, free overnight shipping, 'no hidden fees or memberships' — consultation, prescription, medication and shipping included. verified september 6, 2026.), while PlexusDx starts at $149/month (compounded semaglutide injections $189/mo month-to-month, $169/mo on the 3-month plan and $149/mo on the 6-month plan; compounded tirzepatide injections $289 / $269 / $249. oral semaglutide runs $289 / $269 / $249 and oral tirzepatide $349 / $299 / $279; a low-dose microdose glp-1 program is $129/mo. each price is all-inclusive (provider consult, prescription, medication, supplies and shipping), stays the same at every dose level, and carries no membership fee; nothing is charged until a provider approves the prescription. the site does not say whether the 3- and 6-month tiers are billed up front. an optional glp-1 & peptide pathways genetic test is offered for $99 (list $298) after the first program order. verified october 3, 2026.).
Do Trimi and PlexusDx accept insurance?
Trimi does not accept insurance. PlexusDx does not accept insurance.
Which GLP-1 medications does Trimi offer vs PlexusDx?
Trimi offers Compounded Semaglutide, Compounded Tirzepatide. PlexusDx offers Compounded Semaglutide, Compounded Semaglutide (oral), Compounded Tirzepatide, Compounded Tirzepatide (oral), Microdose GLP-1.
Can I cancel Trimi or PlexusDx at any time?
Trimi allows cancel anytime. PlexusDx also allows cancel anytime.
Are Trimi and PlexusDx available in my state?
Trimi is available in 47 states. PlexusDx is available in all 50 states.
Not sure Trimi or PlexusDx is right for you?
Answer 6 questions and we'll match you with the best program for your budget and goals.