ShedRx vs TMates: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of ShedRx and TMates to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend ShedRx
Between these two providers, ShedRx is our pick for most users. It offers a higher overall rating (8.8 vs 7.8), availability in all 50 states, both brand-name and compounded medication options. That said, TMates may be the better fit if you are looking for users with insurance who want a coached glp-1 program with multiple medication options.
ShedRx scores 8.8/10 in our independent evaluation at $199/month, while TMates scores 7.8/10 at $199/month. Both programs include a licensed physician consultation and ship medication directly to your door. ShedRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | ShedRx | TMates |
|---|---|---|
| Monthly Price | $199 | $199 |
| Rating | 8.8 / 10 | 7.8 / 10 |
| Medication Type | Brand & Compounded | Compounded Only |
| Insurance Accepted | No | Yes |
| States Available | All 50 states | 45 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, health coaching, supplement guidance | Licensed providers, SMS coaching, digital check-ins |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
ShedRx: Detailed Look
ShedRx
150K+ members with 5 medication forms — injections, oral drops, lozenges, tablets, and pills
Pros
- Most delivery forms of any provider: injections, oral drops, lozenges, tablets, and pills
- 10% weight loss guarantee within 9 months or full refund
- Both compounded and brand-name options (Wegovy, Zepbound)
- 150,000+ members, health coaching and supplements included
Cons
- Price increases at higher doses (up to $299/mo)
- Mixed customer service reviews — communication speed can lag
Users who want multiple medication delivery forms and a money-back weight loss guarantee
TMates: Detailed Look
TMates
GLP-1 weight loss program that accepts major insurance plans
Pros
- One of the few GLP-1 providers that accepts major insurance
- Flat-rate pricing includes meds, consults, coaching, and delivery
- 24/7 SMS-based coaching and digital check-ins
- Phentermine option for non-GLP-1 candidates
Cons
- Relatively newer platform with limited independent reviews
- Full program details require enrollment to verify
Users with insurance who want a coached GLP-1 program with multiple medication options
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with ShedRx at $199/month. $199/mo semaglutide starting dose, up to $299/mo at higher doses. Brand pathway $99/mo + pharmacy cost..
ShedRx has the edge with a 8.8 rating.
TMates accepts insurance, which can significantly reduce your out-of-pocket cost.
TMates focuses on compounded medications at a lower price point.
Compare their support: ShedRx offers licensed physicians, health coaching, supplement guidance, while TMates provides licensed providers, sms coaching, digital check-ins.
Frequently Asked Questions
Is ShedRx better than TMates?
ShedRx has a 8.8 rating while TMates has a 7.8 rating. The better choice depends on your priorities — ShedRx is best for users who want multiple medication delivery forms and a money-back weight loss guarantee, while TMates is best for users with insurance who want a coached glp-1 program with multiple medication options.
How much does ShedRx cost compared to TMates?
ShedRx starts at $199/month ($199/mo semaglutide starting dose, up to $299/mo at higher doses. brand pathway $99/mo + pharmacy cost.), while TMates starts at $199/month ($199/mo semaglutide, $297/mo tirzepatide).
Do ShedRx and TMates accept insurance?
ShedRx does not accept insurance. TMates accepts insurance.
Which GLP-1 medications does ShedRx offer vs TMates?
ShedRx offers Compounded Semaglutide, Compounded Tirzepatide, Wegovy, Zepbound. TMates offers Compounded Semaglutide, Compounded Tirzepatide, Phentermine.
Can I cancel ShedRx or TMates at any time?
ShedRx allows cancel anytime. TMates also allows cancel anytime.
Are ShedRx and TMates available in my state?
ShedRx is available in all 50 states. TMates is available in 45 states.