Yucca Health vs SynergyRx: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of Yucca Health and SynergyRx to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend Yucca Health
Between these two providers, Yucca Health is our pick for most users. It offers a higher overall rating (9.2 vs 5.6), more affordable pricing, availability in all 50 states. That said, SynergyRx may be the better fit if you are looking for users who want predictable bundled pricing with 24/7 support access.
Yucca Health scores 9.2/10 in our independent evaluation at $146/month, while SynergyRx scores 5.6/10 at $200/month. Both programs include a licensed physician consultation and ship medication directly to your door. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | Yucca Health | SynergyRx |
|---|---|---|
| Monthly Price | $146 | $200 |
| Rating | 9.2 / 10 | 5.6 / 10 |
| Medication Type | Compounded Only | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | 45 states |
| Consultation Fee | Free | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | No | Yes |
| Medical Support | Licensed U.S. physicians (Dr. Wasef, Dr. Sakla), provider-guided care, 24hr review | Licensed providers, 24/7 messaging, unlimited check-ins |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
Yucca Health: Detailed Look
Yucca Health
LegitScript-certified GLP-1 provider with named physicians and BNPL financing
Pros
- LegitScript certified — pharmacy and telehealth verified
- 4.6/5 Trustpilot rating from 1,000+ verified patient reviews
- Named physicians: Dr. Michael Wasef, MD and Dr. Andrew Sakla, DO
- Buy now, pay later via Klarna, Affirm, and Afterpay
Cons
- Best pricing requires 6-month commitment
- Compounded medications only — no brand-name options
Users who want a LegitScript-certified provider with verified patient reviews and flexible financing
SynergyRx: Detailed Look
SynergyRx
Bundled GLP-1 programs with 24/7 support and no hidden fees
Pros
- All-inclusive bundled pricing — no fees for messaging or adjustments
- Free expedited shipping on all orders
- 24/7 support access with unlimited messaging
- Partners with multiple certified pharmacies for reliability
Cons
- Starting price of $200/mo is mid-range for compounded semaglutide
- May not be available in all 50 states
Users who want predictable bundled pricing with 24/7 support access
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with Yucca Health at $146/month. $146/mo semaglutide on 6-month plan, $258/mo tirzepatide. Klarna/Affirm/Afterpay available..
Yucca Health has the edge with a 9.2 rating.
Yucca Health focuses on compounded medications at a lower price point.
Compare their support: Yucca Health offers licensed u.s. physicians (dr. wasef, dr. sakla), provider-guided care, 24hr review, while SynergyRx provides licensed providers, 24/7 messaging, unlimited check-ins.
SynergyRx at $200/month may offer features that justify the premium.
Frequently Asked Questions
Is Yucca Health better than SynergyRx?
Yucca Health has a 9.2 rating while SynergyRx has a 5.6 rating. The better choice depends on your priorities — Yucca Health is best for users who want a legitscript-certified provider with verified patient reviews and flexible financing, while SynergyRx is best for users who want predictable bundled pricing with 24/7 support access.
How much does Yucca Health cost compared to SynergyRx?
Yucca Health starts at $146/month ($146/mo semaglutide on 6-month plan, $258/mo tirzepatide. klarna/affirm/afterpay available.), while SynergyRx starts at $200/month ($200/mo semaglutide, $299-347/mo tirzepatide).
Do Yucca Health and SynergyRx accept insurance?
Yucca Health does not accept insurance. SynergyRx does not accept insurance.
Which GLP-1 medications does Yucca Health offer vs SynergyRx?
Yucca Health offers Compounded Semaglutide+, Compounded Tirzepatide+. SynergyRx offers Compounded Semaglutide, Compounded Tirzepatide, Ozempic, Wegovy, Mounjaro.
Can I cancel Yucca Health or SynergyRx at any time?
Yucca Health may have cancellation restrictions. SynergyRx also allows cancel anytime.
Are Yucca Health and SynergyRx available in my state?
Yucca Health is available in all 50 states. SynergyRx is available in 45 states.