ShedRx vs Enhance MD: Which GLP-1 Program Is Better? (2026)
A detailed side-by-side comparison of ShedRx and Enhance MD to help you choose the right GLP-1 weight loss program based on pricing, medications, medical support, and more.
Quick Verdict
We recommend ShedRx
Between these two providers, ShedRx is our pick for most users. It offers a higher overall rating (8.8 vs 8.3), more affordable pricing. That said, Enhance MD may be the better fit if you are looking for budget-conscious users interested in combination therapies.
ShedRx scores 8.8/10 in our independent evaluation at $199/month, while Enhance MD scores 8.3/10 at $249/month. Both programs include a licensed physician consultation and ship medication directly to your door. ShedRx also offers oral GLP-1 options for patients who prefer pills over injections. Our rating considers five factors: safety and medical oversight (30%), pricing transparency (25%), cost value (20%), clinical support quality (15%), and onboarding speed (10%). This comparison was independently produced — neither provider pays for placement or higher ratings. Prices verified April 2026.
Side-by-Side Comparison
| Feature | ShedRx | Enhance MD |
|---|---|---|
| Monthly Price | $199 | $249 |
| Rating | 8.8 / 10 | 8.3 / 10 |
| Medication Type | Brand & Compounded | Brand & Compounded |
| Insurance Accepted | No | No |
| States Available | All 50 states | All 50 states |
| Consultation Fee | Included | Included |
| Shipping | Free Shipping | Free Shipping |
| Cancel Anytime | Yes | Yes |
| Medical Support | Licensed physicians, health coaching, supplement guidance | Board-certified physicians |
Prices reflect starting rates without insurance. Actual costs may vary by plan and medication. Last updated April 2026.
ShedRx: Detailed Look
ShedRx
150K+ members with 5 medication forms — injections, oral drops, lozenges, tablets, and pills
Pros
- Most delivery forms of any provider: injections, oral drops, lozenges, tablets, and pills
- 10% weight loss guarantee within 9 months or full refund
- Both compounded and brand-name options (Wegovy, Zepbound)
- 150,000+ members, health coaching and supplements included
Cons
- Price increases at higher doses (up to $299/mo)
- Mixed customer service reviews — communication speed can lag
Users who want multiple medication delivery forms and a money-back weight loss guarantee
Enhance MD: Detailed Look
Enhance MD
Physician-led weight management with NAD+ options
Pros
- Affordable entry point starting at $115/month
- Unique NAD+ therapy option alongside GLP-1
- Board-certified physicians lead all protocols
Cons
- NAD+ weight loss claims lack strong clinical evidence
- Less transparent about which medications are compounded vs brand
Budget-conscious users interested in combination therapies
Which Should You Choose?
The right choice depends on your specific needs and priorities. Here is a quick decision framework:
Go with ShedRx at $199/month. $199/mo semaglutide starting dose, up to $299/mo at higher doses. Brand pathway $99/mo + pharmacy cost..
ShedRx has the edge with a 8.8 rating.
Compare their support: ShedRx offers licensed physicians, health coaching, supplement guidance, while Enhance MD provides board-certified physicians.
Enhance MD at $249/month may offer features that justify the premium.
Frequently Asked Questions
Is ShedRx better than Enhance MD?
ShedRx has a 8.8 rating while Enhance MD has a 8.3 rating. The better choice depends on your priorities — ShedRx is best for users who want multiple medication delivery forms and a money-back weight loss guarantee, while Enhance MD is best for budget-conscious users interested in combination therapies.
How much does ShedRx cost compared to Enhance MD?
ShedRx starts at $199/month ($199/mo semaglutide starting dose, up to $299/mo at higher doses. brand pathway $99/mo + pharmacy cost.), while Enhance MD starts at $249/month (semaglutide $249/mo; tirzepatide $379/mo; annual plans save ~15%).
Do ShedRx and Enhance MD accept insurance?
ShedRx does not accept insurance. Enhance MD does not accept insurance.
Which GLP-1 medications does ShedRx offer vs Enhance MD?
ShedRx offers Compounded Semaglutide, Compounded Tirzepatide, Wegovy, Zepbound. Enhance MD offers Semaglutide, Tirzepatide, NAD+.
Can I cancel ShedRx or Enhance MD at any time?
ShedRx allows cancel anytime. Enhance MD also allows cancel anytime.
Are ShedRx and Enhance MD available in my state?
ShedRx is available in all 50 states. Enhance MD is available in all 50 states.